Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:6869
Official Symbol:TACR1
Other Aliases:NK1R|NKIR|SPR|TAC1R
See related:HGNC:11526|MIM:162323|HPRD:01208
Chromosome:2
Location:2p13.1
Gene Description:tachykinin receptor 1
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0018
ORGANISM:human
Entrez Gene ID:6869
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:21336
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 2
KARG ID:EVID0011
ORGANISM:human
Entrez Gene ID:6869
Evidence Type:Database Annotations
Evidence ID Type:OMIM
Evidence ID:MIM:162323
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
21336CBCerebellum0.469126075506210.594372346997261
21336CTXCerebral cortex0.3904251605272290.377707734704018
21336HIPHippocampal region0.1921220794320110.228253968060017
21336HPFHippocampal formation0.2354774326086040.244905419647694
21336HYHypothalamus0.4992956966161730.538525402545929
21336LSXLateral septal complex1.129010438919071.48940296471119
21336MBMidbrain0.4881830513477330.434229597449303
21336MYMedulla0.7344579398632050.88915753364563
21336OLFOlfactory bulb1.039346233010290.836584612727165
21336PPons0.8749348670244221.12115615606308
21336PALPallidum3.451063275337225.13934147357941
21336RHPRetrohippocampal region0.3136871159076690.263468243181705
21336sAMYStriatum-like amygdalar nuclei3.326459586620333.45665782690048
21336STRStriatum5.519157409667979.10978293418884
21336STRdStriatum dorsal region6.1037952899932911.2818374633789
21336STRvStriatum ventral region6.993243694305429.08639550209045
21336THThalamus1.015353918075560.817692562937737
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
6869GO:0001584IEAFunctionrhodopsin-like receptor activity
6869GO:0004872IEAFunctionreceptor activity
6869GO:0004995IEAFunctiontachykinin receptor activity
6869GO:0004995TASFunctiontachykinin receptor activity
6869GO:0005886IEAComponentplasma membrane
6869GO:0005886TASComponentplasma membrane
6869GO:0005887TASComponentintegral to plasma membrane
6869GO:0006954TASProcessinflammatory response
6869GO:0007165IEAProcesssignal transduction
6869GO:0007186IEAProcessG-protein coupled receptor protein signaling pathway
6869GO:0007200TASProcessG-protein signaling, coupled to IP3 second messenger (phospholipase C activating)
6869GO:0007217TASProcesstachykinin signaling pathway
6869GO:0007638TASProcessmechanosensory behavior
6869GO:0009582TASProcessdetection of abiotic stimulus
6869GO:0016021IEAComponentintegral to membrane
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-255061NP_733786.1tachykinin 4HPRD09701
NP_001049.1--Neurokinin BHPRD01208
NP_001049.1255061-Tachykinin 4HPRD01208
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
6869NK1R_HUMANP25103IPR000276GPCR_RhodpsnRhodopsin-like GPCR superfamily
6869NK1R_HUMANP25103IPR001681Neurokn_rcptNeurokinin receptor
6869NK1R_HUMANP25103IPR000046NK1_rcptNeurokinin NK1 receptor
6869NK1R_HUMANP25103IPR001013NK3_rcptNeurokinin NK3 receptor
6869NK1R_HUMANP25103IPR005395NPFF_rcptNeuropeptide FF receptor
6869NK1R_HUMANP25103IPR000611NPY_rcptNeuropeptide Y receptor
6869NK1R_HUMANP25103IPR002286P2_purnocptorP2 purinoceptor
6869NK1R_HUMANP25103IPR009144Thyrotropin_RHRThyrotropin-releasing hormone receptor

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