Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:6921
Official Symbol:TCEB1
Other Aliases:SIII
See related:HGNC:11617|MIM:600788|HPRD:02875
Chromosome:8
Location:8q21.11
Gene Description:transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C)
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0971
ORGANISM:human
Entrez Gene ID:6921
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:11141048
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Upregulated
Fold Change:1.4 :: 2.4
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
67923CBCerebellum23.198377609252926.2471046447754
67923CTXCerebral cortex45.134269714355532.7808685302734
67923HIPHippocampal region33.081314086914136.3197631835938
67923HPFHippocampal formation38.347564697265636.2562370300293
67923HYHypothalamus15.071641921997111.2334470748901
67923LSXLateral septal complex15.415336608886710.1726989746094
67923MBMidbrain17.575111389160215.8267230987549
67923MYMedulla34.330257415771539.0073623657227
67923OLFOlfactory bulb50.188350677490237.4052238464355
67923PPons31.045276641845734.3325653076172
67923PALPallidum20.12625694274917.4668502807617
67923RHPRetrohippocampal region51.895610809326239.4034614562988
67923sAMYStriatum-like amygdalar nuclei30.716932296752921.8365154266357
67923STRStriatum22.767625808715815.861008644104
67923STRdStriatum dorsal region22.436346054077115.4907369613647
67923STRvStriatum ventral region21.724180221557614.6815614700317
67923THThalamus18.566013336181614.7557344436646
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
6921GO:0003711NRFunctiontranscriptional elongation regulator activity
6921GO:0005515IPIFunctionprotein binding
6921GO:0005634IEAComponentnucleus
6921GO:0006350IEAProcesstranscription
6921GO:0006357TASProcessregulation of transcription from RNA polymerase II promoter
6921GO:0006512IEAProcessubiquitin cycle
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-6924NP_003189.1elongin AHPRD02873
-8651NP_003736.1suppressor of cytokine signaling 1HPRD04669
-9021NP_003946.2suppressor of cytokine signaling 3HPRD05006
-10489NP_006360.3MUF1 proteinHPRD10102
NP_005639.1--VHLHPRD02875
NP_005639.1--Elongin AHPRD02875
NP_005639.1--Elongin BHPRD02875
NP_005639.1--Elongin A2HPRD02875
NP_005639.1--MUF1HPRD02875
NP_005639.1--Elongin A3HPRD02875
NP_005639.1--SOCS-6HPRD02875
NP_005639.1--ASB-8HPRD02875
NP_005639.16924-Transcription elongation factor B, 3HPRD02875
NP_005639.17428-VHLHPRD02875
NP_005639.18651-SOCS1HPRD02875
NP_005639.19021-SOCS3HPRD02875
NP_005639.16923NP_009039.1elongin B isoform aBIND12663
NP_005639.123032NP_055832.3ubiquitin specific protease 33 isoform 1HPRD10297
NP_005639.123032NP_055832.3ubiquitin specific protease 33 isoform 1HPRD02875
NP_005639.1140461NP_077000.1ankyrin repeat and SOCS box-containing 8HPRD10675
NP_005639.1155459NP_057851.1Vif--
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
6921ELOC_HUMANQ15369IPR001232Skp1SKP1 component

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