Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:7018
Official Symbol:TF
Other Aliases:PRO1557|PRO2086
See related:HGNC:11740|MIM:190000|HPRD:01811
Chromosome:3
Location:3q22.1
Gene Description:transferrin
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0175
ORGANISM:human
Entrez Gene ID:7018
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:15312160
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Downregulated
Fold Change:-
KARG Evidence 2
KARG ID:EVIM0411
ORGANISM:human
Entrez Gene ID:7018
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12065639
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Upregulated
Fold Change:-1.6 :: -1.7 :: 4.3 :: 2 :: 2.4 :: 1.2
KARG Evidence 3
KARG ID:EVIM0479
ORGANISM:human
Entrez Gene ID:7018
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12065639
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Motor Cortex
Drug Effects:Upregulated
Fold Change:2.6 :: 2.2 :: -1.3 :: 2.2 :: 1.3
KARG Evidence 4
KARG ID:EVIM0978
ORGANISM:human
Entrez Gene ID:7018
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:11141048
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Downregulated
Fold Change:-3.1 :: -1.9
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
71775CBCerebellum1.907265186309811.61965918540955
22041CBCerebellum56.28142166137775.5939102172852
71775CTXCerebral cortex1.482428073883060.990386545658112
22041CTXCerebral cortex67.786643981933653.2661781311035
71775HIPHippocampal region0.8641378879547120.877530455589294
22041HIPHippocampal region49.062995910644579.7551803588867
71775HPFHippocampal formation1.001688957214360.893962681293488
22041HPFHippocampal formation57.881381988525472.856803894043
71775HYHypothalamus0.1817119568586350.245800778269768
22041HYHypothalamus37.041038513183629.7970352172852
71775LSXLateral septal complex0.183970823884010.119412161409855
22041LSXLateral septal complex35.973106384277327.164831161499
71775MBMidbrain3.044379234313963.16960883140564
22041MBMidbrain38.578006744384836.801944732666
71775MYMedulla0.8485937118530270.584705412387848
22041MYMedulla60.908489227294970.970100402832
71775OLFOlfactory bulb1.29334747791290.952069520950317
22041OLFOlfactory bulb71.805656433105564.1700973510742
71775PPons1.418650865554811.20212125778198
22041PPons43.105384826660247.250358581543
71775PALPallidum0.6185675263404851.26265203952789
22041PALPallidum43.209510803222741.4336280822754
71775RHPRetrohippocampal region1.249185800552370.943567872047424
22041RHPRetrohippocampal region73.876693725585965.3166809082031
71775sAMYStriatum-like amygdalar nuclei1.097509264945980.826548159122467
22041sAMYStriatum-like amygdalar nuclei50.404579162597737.4839401245117
71775STRStriatum0.3625791668891910.372398406267166
22041STRStriatum31.732145309448223.8238086700439
71775STRdStriatum dorsal region0.24046753346920.15566822886467
22041STRdStriatum dorsal region25.422021865844719.3971538543701
71775STRvStriatum ventral region0.4867007136344910.983478128910065
22041STRvStriatum ventral region40.577854156494128.6884174346924
71775THThalamus1.581101059913641.8202406167984
22041THThalamus42.606964111328142.4342575073242
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
7018GO:0005576NASComponentextracellular region
7018GO:0006811IEAProcession transport
7018GO:0006826IEAProcessiron ion transport
7018GO:0006879IEAProcessiron ion homeostasis
7018GO:0008199IEAFunctionferric iron binding
7018GO:0030139IDAComponentendocytic vesicle
7018GO:0046872IEAFunctionmetal ion binding
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-7036NP_003218.2transferrin receptor 2HPRD05282
NP_001054.17036-Transferrin receptor 2HPRD01811
NP_001054.18029NP_001072.1cubilinBIND133317
NP_001054.17037NP_003225.1transferrin receptorHPRD01811
NP_001054.17037NP_003225.1transferrin receptorHPRD01812
NP_001054.17037NP_003225.1transferrin receptorBIND183672
NP_001054.1951475NP_671491.1polyproteinBIND185105
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
7018TRFE_HUMANP02787IPR001156Peptidase_S60Peptidase S60, transferrin lactoferrin

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