Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:7021
Official Symbol:TFAP2B
Other Aliases:AP-2B|AP2-B|CHAR
See related:HGNC:11743|MIM:601601|HPRD:03360
Chromosome:6
Location:6p21-p12
Gene Description:transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0378
ORGANISM:human
Entrez Gene ID:7021
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12065639
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Downregulated
Fold Change:-1.2 :: -1.6 :: -1.6 :: -1.6 :: -1.6 :: -1.1
KARG Evidence 2
KARG ID:EVIM0446
ORGANISM:human
Entrez Gene ID:7021
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12065639
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Motor Cortex
Drug Effects:Downregulated
Fold Change:-1.1 :: 1 :: -1.2 :: -2.9 :: -1.4
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
21419CBCerebellum43.555892944335949.7804336547852
21419CTXCerebral cortex15.74727535247812.7625465393066
21419HIPHippocampal region5.427035331726075.65950632095337
21419HPFHippocampal formation7.856391906738287.77418661117554
21419HYHypothalamus3.116098880767823.91788792610168
21419LSXLateral septal complex0.7370423078536990.805529057979584
21419MBMidbrain10.11902427673348.85814571380615
21419MYMedulla10.314092636108410.5619468688965
21419OLFOlfactory bulb23.401052474975622.2344760894775
21419PPons2.425041437149052.78878903388977
21419PALPallidum1.392069578170781.29621636867523
21419RHPRetrohippocampal region13.325105667114311.8798990249634
21419sAMYStriatum-like amygdalar nuclei5.020483970642093.9567084312439
21419STRStriatum3.684170007705692.91182255744934
21419STRdStriatum dorsal region3.797200202941893.05458855628967
21419STRvStriatum ventral region3.828590631484992.80587100982666
21419THThalamus0.9750440120697021.00357389450073
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
7021GO:0003700NASFunctiontranscription factor activity
7021GO:0003713TASFunctiontranscription coactivator activity
7021GO:0005634IEAComponentnucleus
7021GO:0006350IEAProcesstranscription
7021GO:0006357TASProcessregulation of transcription from RNA polymerase II promoter
7021GO:0007399TASProcessnervous system development
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-163732NP_597724.1Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4HPRD06011
NP_003212.1--ClathrinHPRD03360
NP_003212.1163732-Transcriptional coactivator 4HPRD03360
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
7021AP2B_HUMANQ92481IPR003027Rec1_exonucExonuclease Rec1
7021AP2B_HUMANQ92481IPR004979TF_AP2Transcription factor AP-2
7021AP2B_HUMANQ92481IPR008122TF_AP2_betaTranscription factor AP-2 beta

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