Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:7023
Official Symbol:TFAP4
Other Aliases:AP-4
See related:HGNC:11745|MIM:600743|HPRD:11795
Chromosome:16
Location:16p13
Gene Description:transcription factor AP-4 (activating enhancer binding protein 4)
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0139
ORGANISM:human
Entrez Gene ID:7023
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12629581
Addiction Drug:COCAINE
Addiction Drug Detail:COCAINE ABUSE
Addiction Brain Area:Dorsolateral Prefrontal Cortex
Drug Effects:Upregulated/Downregulated
Fold Change:-2.08 :: -1.32 :: -1.03 :: -1.76 :: 0.33 :: 1.10 :: 0.63
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
83383CBCerebellum21.365915298461924.3725547790527
83383CTXCerebral cortex12.85315513610848.7819299697876
83383HIPHippocampal region18.190822601318419.8193912506104
83383HPFHippocampal formation14.21347236633313.8236894607544
83383HYHypothalamus3.489785432815552.57955884933472
83383LSXLateral septal complex1.27045643329620.882381796836853
83383MBMidbrain5.34152078628544.59393548965454
83383MYMedulla12.26594161987312.2142305374146
83383OLFOlfactory bulb16.818895339965812.7750816345215
83383PPons7.597520351409917.413987159729
83383PALPallidum5.651134014129644.61522912979126
83383RHPRetrohippocampal region7.230714321136475.45745754241943
83383sAMYStriatum-like amygdalar nuclei7.08519935607915.51765632629395
83383STRStriatum7.76819419860845.43184423446655
83383STRdStriatum dorsal region7.68176269531255.41084289550781
83383STRvStriatum ventral region9.861812591552736.35691499710083
83383THThalamus6.772616863250735.15108728408813
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
7023GO:0003705TASFunctionRNA polymerase II transcription factor activity, enhancer binding
7023GO:0003713TASFunctiontranscription coactivator activity
7023GO:0005634IEAComponentnucleus
7023GO:0006357TASProcessregulation of transcription from RNA polymerase II promoter
7023GO:0007275TASProcessdevelopment
7023GO:0030528IEAFunctiontranscription regulator activity
7023GO:0045449IEAProcessregulation of transcription
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
NP_003214.1155871NP_057853.1Tat--
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
7023TFAP4_HUMANQ01664IPR001092HLH_basicBasic helix-loop-helix dimerisation region bHLH
7023TFAP4_HUMANQ01664IPR000694PRO_richProline-rich region

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