Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:7025
Official Symbol:NR2F1
Other Aliases:COUP-TFI|EAR-3|EAR3|ERBAL3|NR2F2|SVP44|TCFCOUP1|TFCOUP1
See related:HGNC:7975|MIM:132890|HPRD:00584
Chromosome:5
Location:5q14
Gene Description:nuclear receptor subfamily 2, group F, member 1
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0197
ORGANISM:human
Entrez Gene ID:7025
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:13865
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
13865CBCerebellum61.004285812377959.1556339263916
13865CTXCerebral cortex100.094.0471267700195
13865HIPHippocampal region77.846286773681685.9352951049805
13865HPFHippocampal formation78.126956939697377.3889999389648
13865HYHypothalamus49.407400131225639.9860687255859
13865LSXLateral septal complex9.388739585876467.12562274932861
13865MBMidbrain30.275662422180228.4366264343262
13865MYMedulla30.879616737365728.1329698562622
13865OLFOlfactory bulb100.0100.0
13865PPons35.263736724853531.7747325897217
13865PALPallidum33.160568237304730.3213224411011
13865RHPRetrohippocampal region74.755290985107462.9826240539551
13865sAMYStriatum-like amygdalar nuclei100.0100.0
13865STRStriatum22.219837188720721.9379930496216
13865STRdStriatum dorsal region9.9361209869384810.2371745109558
13865STRvStriatum ventral region17.554490566253711.9505462646484
13865THThalamus99.0662307739258100.0
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
7025GO:0003700TASFunctiontranscription factor activity
7025GO:0003706TASFunctionligand-regulated transcription factor activity
7025GO:0003707IEAFunctionsteroid hormone receptor activity
7025GO:0003713TASFunctiontranscription coactivator activity
7025GO:0005634IEAComponentnucleus
7025GO:0006350IEAProcesstranscription
7025GO:0006355IEAProcessregulation of transcription, DNA-dependent
7025GO:0007165TASProcesssignal transduction
7025GO:0008270IEAFunctionzinc ion binding
7025GO:0043565IEAFunctionsequence-specific DNA binding
7025GO:0046872IEAFunctionmetal ion binding
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-7067NP_003241.2thyroid hormone receptor, alpha isoform 2HPRD07185
NP_005645.1--General transcription factor IIBHPRD00584
NP_005645.17067-Thyroid hormone receptor alphaHPRD00584
NP_005645.18648NP_003734.3nuclear receptor coactivator 1 isoform 1HPRD00584
NP_005645.18648NP_003734.3nuclear receptor coactivator 1 isoform 1HPRD04070
NP_005645.153335NP_075044.2B-cell CLL/lymphoma 11A isoform 1HPRD00584
NP_005645.153335NP_075044.2B-cell CLL/lymphoma 11A isoform 1HPRD05949
NP_005645.164919NP_612808.1B-cell CLL/lymphoma 11B isoform 1HPRD00584
NP_005645.164919NP_612808.1B-cell CLL/lymphoma 11B isoform 1HPRD05950
NP_005645.1155871NP_057853.1Tat--
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
7025COT1_HUMANP10589IPR003068COUP_TFTranscription factor COUP
7025COT1_HUMANP10589IPR000536Hrmn_rcpt_lig_bdNuclear hormone receptor, ligand-binding
7025COT1_HUMANP10589IPR001628Hrmn_rcpt_DNA_bdNuclear hormone receptor, DNA-binding
7025COT1_HUMANP10589IPR000003RtnoidX_rcptRetinoid X receptor
7025COT1_HUMANP10589IPR003078Rtnoid_rcptRetinoic acid receptor
7025COT1_HUMANP10589IPR001723Str_hrmn_rcptSteroid hormone receptor
7025COT1_HUMANP10589IPR001728ThyrH_rcptThyroid hormone receptor
7025COT1_HUMANP10589IPR000324VitD_rcptVitamin D receptor
7025COT1_HUMANP10589IPR013629Znf-C4_CZinc finger, C4-type, C-terminal

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