Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:7037
Official Symbol:TFRC
Other Aliases:CD71|TFR|TFR1|TRFR
See related:HGNC:11763|MIM:190010|HPRD:01812
Chromosome:3
Location:3q29
Gene Description:transferrin receptor (p90, CD71)
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0420
ORGANISM:human
Entrez Gene ID:7037
Evidence Type:Mapping from rat
Evidence ID Type:Entrez Gene
Evidence ID:64678
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 2
KARG ID:EVIM0084
ORGANISM:human
Entrez Gene ID:7037
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:15009677
Addiction Drug:COCAINE
Addiction Drug Detail:COCAINE ABUSE
Addiction Brain Area:Nucleus Accumbens
Drug Effects:Upregulated
Fold Change:0.66 :: 1.59 :: -0.17 :: -1.60 :: 0.49 :: -0.29 :: 0.40 :: 0.01 :: 1.12 :: 0.30
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
22042CBCerebellum69.767807006835995.6181869506836
22042CTXCerebral cortex100.0100.0
22042HIPHippocampal region95.9998321533203100.0
22042HPFHippocampal formation100.0100.0
22042HYHypothalamus81.648803710937573.10009765625
22042LSXLateral septal complex100.096.6064834594727
22042MBMidbrain87.744712829589886.3988418579102
22042MYMedulla96.4818115234375100.0
22042OLFOlfactory bulb100.0100.0
22042PPons85.0932388305664100.0
22042PALPallidum77.469551086425877.5935516357422
22042RHPRetrohippocampal region100.0100.0
22042sAMYStriatum-like amygdalar nuclei100.090.3382034301758
22042STRStriatum67.945701599121151.8783760070801
22042STRdStriatum dorsal region55.476387023925840.3924713134766
22042STRvStriatum ventral region60.172954559326243.6913681030273
22042THThalamus79.525405883789182.8498764038086
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
7037GO:0004872IEAFunctionreceptor activity
7037GO:0004998NASFunctiontransferrin receptor activity
7037GO:0005576IDAComponentextracellular region
7037GO:0005768IDAComponentendosome
7037GO:0005887TASComponentintegral to plasma membrane
7037GO:0006508IEAProcessproteolysis
7037GO:0006826NRProcessiron ion transport
7037GO:0006879NASProcessiron ion homeostasis
7037GO:0006897IEAProcessendocytosis
7037GO:0008233IEAFunctionpeptidase activity
7037GO:0016020NASComponentmembrane
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
NP_003225.17037NP_003225.1transferrin receptorHPRD01812
NP_003225.111337NP_009209.1GABA(A) receptor-associated proteinHPRD01812
NP_003225.111337NP_009209.1GABA(A) receptor-associated proteinHPRD05496
NP_003225.19744NP_055531.1centaurin beta1BIND183622
NP_003225.1148738NP_998818.1hemojuvelin isoform aHPRD10521
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
7037TFR1_HUMANP02786IPR003137PAProtease-associated PA
7037TFR1_HUMANP02786IPR007365Transf_rcpt_dmrTransferrin receptor-like dimerisation region

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