Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:7040
Official Symbol:TGFB1
Other Aliases:CED|DPD1|TGFB
See related:HGNC:11766|MIM:190180|HPRD:01821
Chromosome:19
Location:19q13.2|19q13.1
Gene Description:transforming growth factor, beta 1 (Camurati-Engelmann disease)
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIL0276
ORGANISM:human
Entrez Gene ID:7040
Evidence Type:LT Reports
Evidence ID Type:PUBMED
Evidence ID:14741421
Addiction Drug:
Addiction Drug Detail:Substance abuse manifest decreased TGF-beta1 expression
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
21803CBCerebellum13.618381917476744.8232719898224
21803CTXCerebral cortex25.979236602783219.4618680477142
21803HIPHippocampal region3.999298632144934.01629829406738
21803HPFHippocampal formation4.198766484856614.04607684910297
21803HYHypothalamus5.699274342507124.99012719094753
21803LSXLateral septal complex1.767371321097021.33223593235016
21803MBMidbrain7.664216905832297.81904163956642
21803MYMedulla11.929588526487414.9830831885338
21803OLFOlfactory bulb19.672843396663716.9459355473518
21803PPons4.666142165660865.87385579943657
21803PALPallidum2.142465122044091.80383490771055
21803RHPRetrohippocampal region4.534190423786644.05565622448921
21803sAMYStriatum-like amygdalar nuclei3.684645086526873.4190034866333
21803STRStriatum3.665168672800062.70779973268509
21803STRdStriatum dorsal region3.17848204076292.1856124997139
21803STRvStriatum ventral region6.137386523187164.57046310603619
21803THThalamus50.169224143028350.1693290024996
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
7040GO:0000074IEAProcessregulation of progression through cell cycle
7040GO:0001501ISSProcessskeletal development
7040GO:0005160ISSFunctiontransforming growth factor beta receptor binding
7040GO:0005515ISSFunctionprotein binding
7040GO:0005578ISSComponentextracellular matrix (sensu Metazoa)
7040GO:0005615ISSComponentextracellular space
7040GO:0006468ISSProcessprotein amino acid phosphorylation
7040GO:0006954ISSProcessinflammatory response
7040GO:0007179ISSProcesstransforming growth factor beta receptor signaling pathway
7040GO:0008083IEAFunctiongrowth factor activity
7040GO:0008219ISSProcesscell death
7040GO:0008283IEAProcesscell proliferation
7040GO:0008284ISSProcesspositive regulation of cell proliferation
7040GO:0008285ISSProcessnegative regulation of cell proliferation
7040GO:0009887ISSProcessorgan morphogenesis
7040GO:0016049IEAProcesscell growth
7040GO:0016202ISSProcessregulation of striated muscle development
7040GO:0016563ISSFunctiontranscriptional activator activity
7040GO:0042306ISSProcessregulation of protein import into nucleus
7040GO:0045893ISSProcesspositive regulation of transcription, DNA-dependent
7040GO:0048298IDAProcesspositive regulation of isotype switching to IgA isotypes
7040GO:0048535ISSProcesslymph node development
7040GO:0051101ISSProcessregulation of DNA binding
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-7448NP_000629.2vitronectin precursorHPRD01902
-7048NP_003233.2transforming growth factor, beta receptor II (70/80kDa)HPRD01823
-7049NP_003234.1transforming growth factor, beta receptor III (betaglycan, 300kDa)HPRD02846
-8425NP_003564.1latent transforming growth factor beta binding protein 4HPRD05274
-8668NP_003748.1eukaryotic translation initiation factor 3, subunit 2 beta, 36kDaHPRD04884
-7531NP_006752.1tyrosine 3/tryptophan 5 -monooxygenase activation protein, epsilon polypeptideHPRD05457
NP_000651.17048-TGF beta receptor, type IIHPRD01821
NP_000651.17049-TGF beta receptor, type 3HPRD01821
NP_000651.18425-Latent TGF beta binding protein 4HPRD01821
NP_000651.18668-TRIP1HPRD01821
NP_000651.17531-14-3-3 epsilonHPRD01821
NP_000651.17448-VitronectinHPRD01821
NP_000651.17042AAA50404.1Human transforming growth factor-beta-2 mRNA, and translated productsHPRD01828
NP_000651.17042AAA50404.1Human transforming growth factor-beta-2 mRNA, and translated productsHPRD01821
NP_000651.17040NP_000651.1transforming growth factor, beta 1HPRD01821
NP_000651.17057NP_003237.1thrombospondin 1HPRD01765
NP_000651.17057NP_003237.1thrombospondin 1HPRD01821
NP_000651.17046NP_004603.1transforming growth factor, beta receptor I precursorHPRD01822
NP_000651.17046NP_004603.1transforming growth factor, beta receptor I precursorHPRD01821
NP_000651.1114990NP_612449.1slit-like 2HPRD10587
NP_000651.1155871NP_057853.1Tat--
NP_000651.1155871NP_057853.1Tat--
NP_000651.1155871NP_057853.1Tat--
NP_000651.27048NP_003233.3transforming growth factor, beta receptor IIBIND194744
NP_000651.27046NP_004603.1transforming growth factor, beta receptor I precursorBIND194747
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
7040TGFB1_HUMANP01137IPR001839TGFbTransforming growth factor beta
7040TGFB1_HUMANP01137IPR003939TGFb1Transforming growth factor, beta 1
7040TGFB1_HUMANP01137IPR001111TGFb_NTransforming growth factor beta (TGFb), N-terminal
7040TGFB1_HUMANP01137IPR003911TGF_TGFbTransforming growth factor beta TGFb

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