Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:7054
Official Symbol:TH
Other Aliases:TYH
See related:HGNC:11782|MIM:191290|HPRD:01865
Chromosome:11
Location:11p15.5
Gene Description:tyrosine hydroxylase
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0070
ORGANISM:human
Entrez Gene ID:7054
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:21823
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 2
KARG ID:EVIL0113
ORGANISM:human
Entrez Gene ID:7054
Evidence Type:LT Reports
Evidence ID Type:PUBMED
Evidence ID:15077008
Addiction Drug:NICOTINE
Addiction Drug Detail:NICOTINE ABUSE
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
21823CBCerebellum2.812476515769967.68430995941162
21823CTXCerebral cortex1.215424120426181.77853590250015
21823HIPHippocampal region0.600411444902420.674923717975616
21823HPFHippocampal formation0.7624458968639370.980039775371552
21823HYHypothalamus11.40890836715717.2091422080994
21823LSXLateral septal complex0.8055249154567720.966499596834183
21823MBMidbrain7.0311810970306419.7072558403015
21823MYMedulla7.9078612327575713.4565176963806
21823OLFOlfactory bulb34.918620109558150.4582796096802
21823PPons3.594635844230658.59521222114563
21823PALPallidum3.901971936225896.16724634170532
21823RHPRetrohippocampal region0.9549351036548611.38001877069473
21823sAMYStriatum-like amygdalar nuclei4.157494425773624.72252333164215
21823STRStriatum3.633827924728395.08419561386108
21823STRdStriatum dorsal region3.611228346824655.49429655075073
21823STRvStriatum ventral region4.322282314300545.2421510219574
21823THThalamus2.022520720958713.56674766540527
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
7054GO:0004497IEAFunctionmonooxygenase activity
7054GO:0004511TASFunctiontyrosine 3-monooxygenase activity
7054GO:0005506IEAFunctioniron ion binding
7054GO:0007268IEAProcesssynaptic transmission
7054GO:0009072IEAProcessaromatic amino acid family metabolism
7054GO:0009653TASProcessmorphogenesis
7054GO:0042136IEAProcessneurotransmitter biosynthesis
7054GO:0042423IEAProcesscatecholamine biosynthesis
7054GO:0046872IEAFunctionmetal ion binding
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
NP_000351.1155871NP_057853.1Tat--
NP_000351.1155871NP_057853.1Tat--
NP_954986.17534NP_003397.1tyrosine 3/tryptophan 5 -monooxygenase activation protein, zeta polypeptideHPRD01865
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
7054IPR001273Aaa_hydroxylaseAromatic amino acid hydroxylase
7054IPR000104Antifreeze_1Antifreeze protein, type I
7054TY3H_HUMANP07101IPR001273Aaa_hydroxylaseAromatic amino acid hydroxylase
7054TY3H_HUMANP07101IPR000104Antifreeze_1Antifreeze protein, type I

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