Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:7068
Official Symbol:THRB
Other Aliases:ERBA-BETA|ERBA2|GRTH|MGC126109|MGC126110|NR1A2|THR1|THRB1|THRB2
See related:HGNC:11799|MIM:190160|HPRD:07521
Chromosome:3
Location:3p24.2
Gene Description:thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian)
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0403
ORGANISM:human
Entrez Gene ID:7068
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12065639
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Downregulated
Fold Change:1.3 :: -1.4 :: -1.6 :: -1.7 :: -1.7 :: -1.6
KARG Evidence 2
KARG ID:EVIM0471
ORGANISM:human
Entrez Gene ID:7068
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12065639
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Motor Cortex
Drug Effects:Downregulated
Fold Change:-1.1 :: -1.1 :: -1.3 :: -2.3 :: -1.4
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
21834CBCerebellum3.827431440353394.56477212905884
21834CTXCerebral cortex72.376550674438563.6972980499268
21834HIPHippocampal region25.334372520446834.8466176986694
21834HPFHippocampal formation37.976708412170442.5175857543945
21834HYHypothalamus4.550369024276733.64441359043121
21834LSXLateral septal complex62.733078002929760.4139823913574
21834MBMidbrain5.263771533966065.26414728164673
21834MYMedulla7.724782705307018.42277073860168
21834OLFOlfactory bulb32.555656433105526.7780828475952
21834PPons6.394618988037116.65611577033997
21834PALPallidum7.962101221084596.54614508152008
21834RHPRetrohippocampal region56.988574981689551.8793926239014
21834sAMYStriatum-like amygdalar nuclei15.324069499969511.2567607164383
21834STRStriatum24.662790298461918.591724395752
21834STRdStriatum dorsal region21.318304538726815.3663387298584
21834STRvStriatum ventral region25.423586845397916.8339262008667
21834THThalamus4.662359833717353.84751415252686
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
7068GO:0003700NASFunctiontranscription factor activity
7068GO:0003707IEAFunctionsteroid hormone receptor activity
7068GO:0003714TASFunctiontranscription corepressor activity
7068GO:0004887TASFunctionthyroid hormone receptor activity
7068GO:0005515IPIFunctionprotein binding
7068GO:0005634TASComponentnucleus
7068GO:0006355IEAProcessregulation of transcription, DNA-dependent
7068GO:0007605IEAProcesssensory perception of sound
7068GO:0008270IEAFunctionzinc ion binding
7068GO:0043565IEAFunctionsequence-specific DNA binding
7068GO:0046872IEAFunctionmetal ion binding
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-7157NP_000537.2tumor protein p53HPRD01859
-9318NP_004227.1COP9 constitutive photomorphogenic homolog subunit 2HPRD05146
-9320NP_004229.1thyroid hormone receptor interactor 12HPRD05144
-221037NP_004232.1jumonji domain containing 1CHPRD05141
-10499NP_006531.1nuclear receptor coactivator 2HPRD09066
-10891NP_037393.1peroxisome proliferative activated receptor gamma coactivator 1HPRD05155
-51102NP_057095.1nuclear receptor-binding factor 1HPRD12192
-29982NP_110386.1nuclear receptor binding factor 2HPRD11401
NP_000452.2221037-Thyroid hormone receptor interactor 8HPRD07521
NP_000452.29318-Thyroid hormone receptor interactor 15HPRD07521
NP_000452.29320-Thyroid hormone receptor interactor 12HPRD07521
NP_000452.27157-p53HPRD07521
NP_000452.210499-TIF2HPRD07521
NP_000452.210891-PPAR gamma coactivator 1HPRD07521
NP_000452.28202AAB92368.1Homo sapiens nuclear receptor coactivator (ACTR) mRNA, complete cds.BIND151492
NP_000452.28648NP_003734.3nuclear receptor coactivator 1 isoform 1HPRD04070
NP_000452.28648NP_003734.3nuclear receptor coactivator 1 isoform 1HPRD07521
NP_000452.28841NP_003874.2histone deacetylase 3HPRD07521
NP_000452.29412NP_004255.2SRB7 suppressor of RNA polymerase B homologBIND151629
NP_000452.28125NP_006296.1acidic (leucine-rich) nuclear phosphoprotein 32 family, member ABIND154080
NP_000452.210499NP_006531.1nuclear receptor coactivator 2BIND151883
NP_000452.210664NP_006556.1CCCTC-binding factorBIND151099
NP_000452.29325NP_057297.2thyroid hormone receptor interactor 4HPRD07521
NP_000452.29325NP_057297.2thyroid hormone receptor interactor 4HPRD05140
NP_000452.229893NP_057640.1TBP-1 interacting protein isoform 2HPRD16362
NP_000452.28648NP_671766.1nuclear receptor coactivator 1 isoform 3BIND151621
NP_000452.28202NP_858045.1nuclear receptor coactivator 3 isoform aBIND151485
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
7068THB1_HUMANP10828IPR000536Hrmn_rcpt_lig_bdNuclear hormone receptor, ligand-binding
7068THB1_HUMANP10828IPR001628Hrmn_rcpt_DNA_bdNuclear hormone receptor, DNA-binding
7068THB1_HUMANP10828IPR003078Rtnoid_rcptRetinoic acid receptor
7068THB1_HUMANP10828IPR001723Str_hrmn_rcptSteroid hormone receptor
7068THB1_HUMANP10828IPR001728ThyrH_rcptThyroid hormone receptor
7068THB1_HUMANP10828IPR000324VitD_rcptVitamin D receptor
7068THB1_HUMANP10828IPR013629Znf-C4_CZinc finger, C4-type, C-terminal

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