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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry

For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information Gene ID: 7068 Official Symbol: THRB Other Aliases: ERBA-BETA|ERBA2|GRTH|MGC126109|MGC126110|NR1A2|THR1|THRB1|THRB2 See related: HGNC:11799|MIM:190160|HPRD:07521 Chromosome: 3 Location: 3p24.2 Gene Description: thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian) Gene type: protein-coding Gene Structure: Genomic Context: KARG Evidence 1 KARG ID: EVIM0403 ORGANISM: human Entrez Gene ID: 7068 Evidence Type: Microarray Evidence ID Type: PUBMED Evidence ID: 12065639 Addiction Drug: ALCOHOL Addiction Drug Detail: ALCOHOL ABUSE Addiction Brain Area: Frontal Cortex Drug Effects: Downregulated Fold Change: 1.3 :: -1.4 :: -1.6 :: -1.7 :: -1.7 :: -1.6 KARG Evidence 2 KARG ID: EVIM0471 ORGANISM: human Entrez Gene ID: 7068 Evidence Type: Microarray Evidence ID Type: PUBMED Evidence ID: 12065639 Addiction Drug: ALCOHOL Addiction Drug Detail: ALCOHOL ABUSE Addiction Brain Area: Motor Cortex Drug Effects: Downregulated Fold Change: -1.1 :: -1.1 :: -1.3 :: -2.3 :: -1.4 Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas) Mouse Entrez Gene ID Brain Region Brain Region Detail Expression Level Expression Density 21834 CB Cerebellum 3.82743144035339 4.56477212905884 21834 CTX Cerebral cortex 72.3765506744385 63.6972980499268 21834 HIP Hippocampal region 25.3343725204468 34.8466176986694 21834 HPF Hippocampal formation 37.9767084121704 42.5175857543945 21834 HY Hypothalamus 4.55036902427673 3.64441359043121 21834 LSX Lateral septal complex 62.7330780029297 60.4139823913574 21834 MB Midbrain 5.26377153396606 5.26414728164673 21834 MY Medulla 7.72478270530701 8.42277073860168 21834 OLF Olfactory bulb 32.5556564331055 26.7780828475952 21834 P Pons 6.39461898803711 6.65611577033997 21834 PAL Pallidum 7.96210122108459 6.54614508152008 21834 RHP Retrohippocampal region 56.9885749816895 51.8793926239014 21834 sAMY Striatum-like amygdalar nuclei 15.3240694999695 11.2567607164383 21834 STR Striatum 24.6627902984619 18.591724395752 21834 STRd Striatum dorsal region 21.3183045387268 15.3663387298584 21834 STRv Striatum ventral region 25.4235868453979 16.8339262008667 21834 TH Thalamus 4.66235983371735 3.84751415252686 Gene Ontology Gene ID GO ID Evidence GO Type GO Description 7068 GO:0003700 NAS Function transcription factor activity 7068 GO:0003707 IEA Function steroid hormone receptor activity 7068 GO:0003714 TAS Function transcription corepressor activity 7068 GO:0004887 TAS Function thyroid hormone receptor activity 7068 GO:0005515 IPI Function protein binding 7068 GO:0005634 TAS Component nucleus 7068 GO:0006355 IEA Process regulation of transcription, DNA-dependent 7068 GO:0007605 IEA Process sensory perception of sound 7068 GO:0008270 IEA Function zinc ion binding 7068 GO:0043565 IEA Function sequence-specific DNA binding 7068 GO:0046872 IEA Function metal ion binding Interaction Information Gene Product ID Interactant Gene ID Interactant Gene Product ID Interactant Gene Product Name Source Source ID - 7157 NP_000537.2 tumor protein p53 HPRD 01859 - 9318 NP_004227.1 COP9 constitutive photomorphogenic homolog subunit 2 HPRD 05146 - 9320 NP_004229.1 thyroid hormone receptor interactor 12 HPRD 05144 - 221037 NP_004232.1 jumonji domain containing 1C HPRD 05141 - 10499 NP_006531.1 nuclear receptor coactivator 2 HPRD 09066 - 10891 NP_037393.1 peroxisome proliferative activated receptor gamma coactivator 1 HPRD 05155 - 51102 NP_057095.1 nuclear receptor-binding factor 1 HPRD 12192 - 29982 NP_110386.1 nuclear receptor binding factor 2 HPRD 11401 NP_000452.2 221037 - Thyroid hormone receptor interactor 8 HPRD 07521 NP_000452.2 9318 - Thyroid hormone receptor interactor 15 HPRD 07521 NP_000452.2 9320 - Thyroid hormone receptor interactor 12 HPRD 07521 NP_000452.2 7157 - p53 HPRD 07521 NP_000452.2 10499 - TIF2 HPRD 07521 NP_000452.2 10891 - PPAR gamma coactivator 1 HPRD 07521 NP_000452.2 8202 AAB92368.1 Homo sapiens nuclear receptor coactivator (ACTR) mRNA, complete cds. BIND 151492 NP_000452.2 8648 NP_003734.3 nuclear receptor coactivator 1 isoform 1 HPRD 04070 NP_000452.2 8648 NP_003734.3 nuclear receptor coactivator 1 isoform 1 HPRD 07521 NP_000452.2 8841 NP_003874.2 histone deacetylase 3 HPRD 07521 NP_000452.2 9412 NP_004255.2 SRB7 suppressor of RNA polymerase B homolog BIND 151629 NP_000452.2 8125 NP_006296.1 acidic (leucine-rich) nuclear phosphoprotein 32 family, member A BIND 154080 NP_000452.2 10499 NP_006531.1 nuclear receptor coactivator 2 BIND 151883 NP_000452.2 10664 NP_006556.1 CCCTC-binding factor BIND 151099 NP_000452.2 9325 NP_057297.2 thyroid hormone receptor interactor 4 HPRD 07521 NP_000452.2 9325 NP_057297.2 thyroid hormone receptor interactor 4 HPRD 05140 NP_000452.2 29893 NP_057640.1 TBP-1 interacting protein isoform 2 HPRD 16362 NP_000452.2 8648 NP_671766.1 nuclear receptor coactivator 1 isoform 3 BIND 151621 NP_000452.2 8202 NP_858045.1 nuclear receptor coactivator 3 isoform a BIND 151485 Domain Information Gene ID Uniprot/Swissprot ID Uniprot/Swissprot ACC Interpro ID Interpro Short Description Interpro Long Description 7068 THB1_HUMAN P10828 IPR000536 Hrmn_rcpt_lig_bd Nuclear hormone receptor, ligand-binding 7068 THB1_HUMAN P10828 IPR001628 Hrmn_rcpt_DNA_bd Nuclear hormone receptor, DNA-binding 7068 THB1_HUMAN P10828 IPR003078 Rtnoid_rcpt Retinoic acid receptor 7068 THB1_HUMAN P10828 IPR001723 Str_hrmn_rcpt Steroid hormone receptor 7068 THB1_HUMAN P10828 IPR001728 ThyrH_rcpt Thyroid hormone receptor 7068 THB1_HUMAN P10828 IPR000324 VitD_rcpt Vitamin D receptor 7068 THB1_HUMAN P10828 IPR013629 Znf-C4_C Zinc finger, C4-type, C-terminal © Center for Bioinformatics(CBI), Peking University Any Comments and suggestions to : KARG GROUP.