Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:7074
Official Symbol:TIAM1
Other Aliases:-
See related:HGNC:11805|MIM:600687|HPRD:02820
Chromosome:21
Location:21q22.1|21q22.11
Gene Description:T-cell lymphoma invasion and metastasis 1
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0358
ORGANISM:human
Entrez Gene ID:7074
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:15816859
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Nucleus Accumbens
Drug Effects:Downregulated
Fold Change:-0.60
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
21844CBCerebellum100.0100.0
21844CTXCerebral cortex67.391543388366756.6033234596252
21844HIPHippocampal region75.49500560760587.229549407959
21844HPFHippocampal formation79.020566940307685.0762634277344
21844HYHypothalamus21.623210012912816.7689916193485
21844LSXLateral septal complex75.303919792175371.7020397186279
21844MBMidbrain23.288166761398321.3817261457443
21844MYMedulla33.775799274444636.1427299976349
21844OLFOlfactory bulb100.0100.0
21844PPons25.195345401763925.5899202823639
21844PALPallidum38.559383869171136.5860433578491
21844RHPRetrohippocampal region85.904479980468878.6351337432861
21844sAMYStriatum-like amygdalar nuclei71.932102203369161.4797821044922
21844STRStriatum68.355237960815463.2887697219849
21844STRdStriatum dorsal region54.430761814117447.3939528465271
21844STRvStriatum ventral region97.536037445068489.4587440490723
21844THThalamus87.283811569213991.9496326446533
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
7074GO:0005057IEAFunctionreceptor signaling protein activity
7074GO:0005089TASFunctionRho guanyl-nucleotide exchange factor activity
7074GO:0005515IEAFunctionprotein binding
7074GO:0005622IEAComponentintracellular
7074GO:0007242IEAProcessintracellular signaling cascade
7074GO:0035023IEAProcessregulation of Rho protein signal transduction
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-9479NP_005447.1mitogen-activated protein kinase 8 interacting protein 1HPRD05223
-84687NP_115984.1protein phosphatase 1, regulatory subunit 9BHPRD04506
NP_003244.1--Protein phosphatase 1HPRD02820
NP_003244.1--Protein phosphatase 2BHPRD02820
NP_003244.1--IB2HPRD02820
NP_003244.19479-MAPK8 interacting protein 1HPRD02820
NP_003244.184687-PPP1R9BHPRD02820
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
7074TIAM1_HUMANQ13009IPR001331GDS_CDC24Guanine-nucleotide dissociation stimulator, CDC24
7074TIAM1_HUMANQ13009IPR001478PDZPDZ/DHR/GLGF
7074TIAM1_HUMANQ13009IPR001849PHPleckstrin-like
7074TIAM1_HUMANQ13009IPR003116Raf_like_ras_bdRaf-like Ras-binding
7074TIAM1_HUMANQ13009IPR000219RhoGEFDH
7074TIAM1_HUMANQ13009IPR001605Spectrin_PHSpectrin/pleckstrin-like

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