Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:7076
Official Symbol:TIMP1
Other Aliases:CLGI|EPA|EPO|FLJ90373|HCI|TIMP
See related:HGNC:11820|MIM:305370|HPRD:02371
Chromosome:X
Location:Xp11.3-p11.23
Gene Description:TIMP metallopeptidase inhibitor 1
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0373
ORGANISM:human
Entrez Gene ID:7076
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12065639
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Downregulated
Fold Change:1.2 :: 1.2 :: -1.4 :: -2 :: -1.7 :: -2.1
KARG Evidence 2
KARG ID:EVIM0441
ORGANISM:human
Entrez Gene ID:7076
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12065639
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Motor Cortex
Drug Effects:Downregulated
Fold Change:-1 :: 1.1 :: -1.5 :: -3.2 :: -1.1
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
21857CBCerebellum3.781058073043824.78894948959351
21857CTXCerebral cortex3.712824583053592.99395084381104
21857HIPHippocampal region2.420279502868653.42390823364258
21857HPFHippocampal formation2.199649333953862.95528507232666
21857HYHypothalamus8.272653579711917.10981607437134
21857LSXLateral septal complex3.583503246307372.65685963630676
21857MBMidbrain4.690256595611575.13963317871094
21857MYMedulla8.1575536727905310.332311630249
21857OLFOlfactory bulb13.475478172302212.4018974304199
21857PPons7.9821500778198210.1833820343018
21857PALPallidum1.868642926216132.09698987007141
21857RHPRetrohippocampal region1.290653705596921.50283324718475
21857sAMYStriatum-like amygdalar nuclei2.611058950424191.80596148967743
21857STRStriatum2.468403816223142.15576410293579
21857STRdStriatum dorsal region0.8428256511688230.822242796421051
21857STRvStriatum ventral region8.243172645568857.15925741195679
21857THThalamus5.06943750381473.89688420295715
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
7076GO:0004857IEAFunctionenzyme inhibitor activity
7076GO:0005578IEAComponentextracellular matrix (sensu Metazoa)
7076GO:0007275NRProcessdevelopment
7076GO:0008191IDAFunctionmetalloendopeptidase inhibitor activity
7076GO:0008191IEAFunctionmetalloendopeptidase inhibitor activity
7076GO:0008284TASProcesspositive regulation of cell proliferation
7076GO:0043249IEAProcesserythrocyte maturation
7076GO:0051045IDAProcessnegative regulation of membrane protein ectodomain proteolysis
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
NP_003245.1155871NP_057853.1Tat--
NP_003245.1155871NP_057853.1Tat--
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
7076TIMP1_HUMANP01033IPR001820Prot_inh_TIMPProteinase inhibitor I35, tissue inhibitor of metalloproteinase

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