Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:7077
Official Symbol:TIMP2
Other Aliases:CSC-21K
See related:HGNC:11821|MIM:188825|HPRD:01784
Chromosome:17
Location:17q25
Gene Description:TIMP metallopeptidase inhibitor 2
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0341
ORGANISM:human
Entrez Gene ID:7077
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:15816859
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Nucleus Accumbens
Drug Effects:Downregulated
Fold Change:-0.58
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
21858CBCerebellum91.317890167236392.448802947998
21858CTXCerebral cortex100.0100.0
21858HIPHippocampal region100.0100.0
21858HPFHippocampal formation100.0100.0
21858HYHypothalamus100.0100.0
21858LSXLateral septal complex100.0100.0
21858MBMidbrain100.0100.0
21858MYMedulla100.0100.0
21858OLFOlfactory bulb100.0100.0
21858PPons100.0100.0
21858PALPallidum100.0100.0
21858RHPRetrohippocampal region100.0100.0
21858sAMYStriatum-like amygdalar nuclei100.0100.0
21858STRStriatum100.0100.0
21858STRdStriatum dorsal region100.091.6551361083984
21858STRvStriatum ventral region100.0100.0
21858THThalamus100.0100.0
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
7077GO:0004857IEAFunctionenzyme inhibitor activity
7077GO:0005578IEAComponentextracellular matrix (sensu Metazoa)
7077GO:0008191TASFunctionmetalloendopeptidase inhibitor activity
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
NP_003246.1155871NP_057853.1Tat--
NP_003246.1155871NP_057853.1Tat--
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
7077TIMP2_HUMANP16035IPR001820Prot_inh_TIMPProteinase inhibitor I35, tissue inhibitor of metalloproteinase

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