Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:7078
Official Symbol:TIMP3
Other Aliases:HSMRK222|K222|K222TA2|SFD
See related:HGNC:11822|MIM:188826|HPRD:01785
Chromosome:22
Location:22q12.1-q13.2|22q12.3
Gene Description:TIMP metallopeptidase inhibitor 3 (Sorsby fundus dystrophy, pseudoinflammatory)
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0295
ORGANISM:human
Entrez Gene ID:7078
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:15816859
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Prefrontal Cortex
Drug Effects:Upregulated
Fold Change:0.71
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
21859CBCerebellum46.062208175659278.0736274719238
21859CTXCerebral cortex47.824996948242239.2861833572388
21859HIPHippocampal region34.558706283569349.9575748443604
21859HPFHippocampal formation36.550481796264644.9533653259277
21859HYHypothalamus49.824266433715848.9159030914307
21859LSXLateral septal complex39.318290710449244.813533782959
21859MBMidbrain37.522871971130447.3406620025635
21859MYMedulla39.422756195068451.9666709899902
21859OLFOlfactory bulb69.585306167602561.6383266448975
21859PPons46.795104980468854.4174976348877
21859PALPallidum35.645480155944836.6421680450439
21859RHPRetrohippocampal region39.265264511108437.6568508148193
21859sAMYStriatum-like amygdalar nuclei44.707082748413140.4790115356445
21859STRStriatum36.723083496093834.1957244873047
21859STRdStriatum dorsal region31.803229331970229.6442022323608
21859STRvStriatum ventral region45.612701416015635.7694597244263
21859THThalamus90.58606719970798.4776229858398
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
7078GO:0004857IEAFunctionenzyme inhibitor activity
7078GO:0005554NDFunctionmolecular function unknown
7078GO:0005578IEAComponentextracellular matrix (sensu Metazoa)
7078GO:0005578NASComponentextracellular matrix (sensu Metazoa)
7078GO:0007169NASProcesstransmembrane receptor protein tyrosine kinase signaling pathway
7078GO:0007601IEAProcessvisual perception
7078GO:0008191IEAFunctionmetalloendopeptidase inhibitor activity
7078GO:0008624NASProcessinduction of apoptosis by extracellular signals
7078GO:0050896IEAProcessresponse to stimulus
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
NP_000353.1--Gelatinase AHPRD01785
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
7078TIMP3_HUMANP35625IPR001820Prot_inh_TIMPProteinase inhibitor I35, tissue inhibitor of metalloproteinase

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