Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:7080
Official Symbol:TITF1
Other Aliases:BCH|BHC|NK-2|NKX2.1|NKX2A|TEBP|TTF-1|TTF1
See related:HGNC:11825|MIM:600635|HPRD:02798
Chromosome:14
Location:14q13
Gene Description:thyroid transcription factor 1
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0372
ORGANISM:human
Entrez Gene ID:7080
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12065639
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Downregulated
Fold Change:-1.4 :: -1.1 :: -1.3 :: -1.5 :: -1.5 :: -1.6
KARG Evidence 2
KARG ID:EVIM0440
ORGANISM:human
Entrez Gene ID:7080
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12065639
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Motor Cortex
Drug Effects:Downregulated
Fold Change:1 :: -1.1 :: -1.3 :: -2.1 :: -1.5
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
21869CBCerebellum100.0100.0
21869CTXCerebral cortex100.0100.0
21869HIPHippocampal region100.0100.0
21869HPFHippocampal formation100.0100.0
21869HYHypothalamus100.0100.0
21869LSXLateral septal complex100.0100.0
21869MBMidbrain100.0100.0
21869MYMedulla100.0100.0
21869OLFOlfactory bulb100.0100.0
21869PPons100.0100.0
21869PALPallidum100.0100.0
21869RHPRetrohippocampal region100.0100.0
21869sAMYStriatum-like amygdalar nuclei100.0100.0
21869STRStriatum100.0100.0
21869STRdStriatum dorsal region100.0100.0
21869STRvStriatum ventral region100.0100.0
21869THThalamus100.0100.0
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
7080GO:0003700IEAFunctiontranscription factor activity
7080GO:0005634NASComponentnucleus
7080GO:0006355NASProcessregulation of transcription, DNA-dependent
7080GO:0016563NASFunctiontranscriptional activator activity
7080GO:0043565IEAFunctionsequence-specific DNA binding
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-8648NP_003734.3nuclear receptor coactivator 1 isoform 1HPRD04070
-28996NP_073577.1homeodomain interacting protein kinase 2HPRD06039
NP_003308.1--TIF2HPRD02798
NP_003308.18648-SRC1HPRD02798
NP_003308.128996-Homeodomain interacting protein kinase 2HPRD02798
NP_003308.17849NP_003457.1paired box gene 8 isoform PAX8AHPRD02798
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
7080TITF1_HUMANP43699IPR001356HomeoboxHomeobox
7080TITF1_HUMANP43699IPR000047HTH_lambrepressrHelix-turn-helix motif, lambda-like repressor

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