Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:7086
Official Symbol:TKT
Other Aliases:TKT1
See related:HGNC:11834|MIM:606781|HPRD:06001
Chromosome:3
Location:3p14.3
Gene Description:transketolase (Wernicke-Korsakoff syndrome)
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0502
ORGANISM:human
Entrez Gene ID:7086
Evidence Type:Mapping from rat
Evidence ID Type:Entrez Gene
Evidence ID:64524
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 2
KARG ID:EVIP0252
ORGANISM:human
Entrez Gene ID:7086
Evidence Type:Proteomics
Evidence ID Type:PUBMED
Evidence ID:16172612
Addiction Drug:ALCOHOL
Addiction Drug Detail:Chronic alcohol use
Addiction Brain Area:Brain
Drug Effects:Downregulated
Fold Change:-1.4::-1.3
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
21881CBCerebellum47.384483337402370.755729675293
21881CTXCerebral cortex59.35460662841849.2372436523438
21881HIPHippocampal region31.965101242065444.2261428833008
21881HPFHippocampal formation35.802234649658240.6560478210449
21881HYHypothalamus67.014450073242261.8831443786621
21881LSXLateral septal complex48.465019226074241.9443473815918
21881MBMidbrain42.348899841308642.2944984436035
21881MYMedulla38.848442077636745.2540473937988
21881OLFOlfactory bulb74.298736572265674.4997100830078
21881PPons41.622676849365248.4119148254395
21881PALPallidum55.361217498779357.0216522216797
21881RHPRetrohippocampal region43.254302978515635.994514465332
21881sAMYStriatum-like amygdalar nuclei56.815032958984447.473217010498
21881STRStriatum41.305511474609433.8823852539062
21881STRdStriatum dorsal region34.008823394775427.4987449645996
21881STRvStriatum ventral region51.641567230224640.266788482666
21881THThalamus51.80870819091850.1719551086426
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
7086GO:0004802TASFunctiontransketolase activity
7086GO:0005509IEAFunctioncalcium ion binding
7086GO:0016740IEAFunctiontransferase activity
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
NP_001055.17086NP_001055.1transketolaseHPRD06001
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
7086TKT_HUMANP29401IPR005474Transketo_NTransketolase, N-terminal
7086TKT_HUMANP29401IPR005475Transketo_Cen_RTransketolase, central region
7086TKT_HUMANP29401IPR005476Transketo_CTransketolase, C-terminal
7086TKT_HUMANP29401IPR012058Transketo_N_RTransketolase N-terminal region

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