Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:7113
Official Symbol:TMPRSS2
Other Aliases:PRSS10
See related:HGNC:11876|MIM:602060|HPRD:03637
Chromosome:21
Location:21q22.3
Gene Description:transmembrane protease, serine 2
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0846
ORGANISM:human
Entrez Gene ID:7113
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:11141048
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Upregulated
Fold Change:1.4 :: 1.6
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
7113GO:0004252IEAFunctionserine-type endopeptidase activity
7113GO:0005044IEAFunctionscavenger receptor activity
7113GO:0005887TASComponentintegral to plasma membrane
7113GO:0006508IEAProcessproteolysis
7113GO:0016020IEAComponentmembrane
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
7113TMPS2_HUMANO15393IPR002172LDL_rcpt_ALow density lipoprotein-receptor, class A
7113TMPS2_HUMANO15393IPR001254Peptidase_S1_S6Peptidase S1 and S6, chymotrypsin/Hap
7113TMPS2_HUMANO15393IPR001314Peptidase_S1APeptidase S1A, chymotrypsin
7113TMPS2_HUMANO15393IPR008256Peptidase_S1BPeptidase S1B, glutamyl endopeptidase I
7113TMPS2_HUMANO15393IPR001190Srcr_rcptSperact/scavenger receptor

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