Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:7122
Official Symbol:CLDN5
Other Aliases:AWAL|BEC1|CPETRL1|TMVCF
See related:HGNC:2047|MIM:602101|HPRD:03654
Chromosome:22
Location:22q11.21
Gene Description:claudin 5 (transmembrane protein deleted in velocardiofacial syndrome)
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0315
ORGANISM:human
Entrez Gene ID:7122
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:12741
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
12741CBCerebellum18.724267959594729.1833381652832
12741CTXCerebral cortex30.404184341430727.0690631866455
12741HIPHippocampal region23.724098205566428.0708980560303
12741HPFHippocampal formation22.725059509277325.8355617523193
12741HYHypothalamus17.365503311157218.1966018676758
12741LSXLateral septal complex21.400669097900422.4951515197754
12741MBMidbrain12.470428466796917.591833114624
12741MYMedulla6.036919116973889.72427272796631
12741OLFOlfactory bulb34.441001892089835.6262397766113
12741PPons8.3287210464477512.0564727783203
12741PALPallidum17.428636550903317.7331295013428
12741RHPRetrohippocampal region20.426359176635722.1863536834717
12741sAMYStriatum-like amygdalar nuclei18.490390777587917.7947673797607
12741STRStriatum20.018220901489317.3323860168457
12741STRdStriatum dorsal region20.689317703247117.4666385650635
12741STRvStriatum ventral region18.284168243408214.5812139511108
12741THThalamus22.835275650024424.3809394836426
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
7122GO:0005198IEAFunctionstructural molecule activity
7122GO:0005923ISSComponenttight junction
7122GO:0016020IEAComponentmembrane
7122GO:0016021ISSComponentintegral to membrane
7122GO:0016338ISSProcesscalcium-independent cell-cell adhesion
7122GO:0042802ISSFunctionidentical protein binding
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
NP_003268.1--MUPP1HPRD03654
NP_003268.17122NP_003268.1claudin 5HPRD03654
NP_003268.1155871NP_057853.1Tat--
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
7122CLD5_HUMANO00501IPR006187ClaudinClaudin tight junction protein
7122CLD5_HUMANO00501IPR003556Claudin14Claudin-14
7122CLD5_HUMANO00501IPR005411Claudin2Claudin-2
7122CLD5_HUMANO00501IPR003551Claudin5Claudin-5
7122CLD5_HUMANO00501IPR004031PMP22_ClaudinPMP-22/EMP/MP20 and claudin

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