Knowledgebase for Addiction-Related Genes
Home | Score | Chromosome | Pathway | Advanced Search | BLAST Search | Downloads | Publications | FAQ & Help |   

KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:7124
Official Symbol:TNF
Other Aliases:DIF|TNF-alpha|TNFA|TNFSF2
See related:HGNC:11892|MIM:191160|HPRD:01855
Chromosome:6
Location:6p21.3
Gene Description:tumor necrosis factor (TNF superfamily, member 2)
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIL0128
ORGANISM:human
Entrez Gene ID:7124
Evidence Type:LT Reports
Evidence ID Type:PUBMED
Evidence ID:15339882
Addiction Drug:NICOTINE
Addiction Drug Detail:NICOTINE ABUSE
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
21926CBCerebellum4.058911800384524.47026109695435
21926CTXCerebral cortex4.611767768859863.39234590530396
21926HIPHippocampal region3.83323144912723.76007008552551
21926HPFHippocampal formation3.968294382095343.50812315940857
21926HYHypothalamus3.431557416915892.62970209121704
21926LSXLateral septal complex0.05612387135624890.0
21926MBMidbrain1.874414086341862.04403448104858
21926MYMedulla2.869919538497923.14716553688049
21926OLFOlfactory bulb10.22530174255377.25236654281616
21926PPons4.804842948913575.04539585113525
21926PALPallidum6.332573890686045.48863983154297
21926RHPRetrohippocampal region4.256145954132083.22043561935425
21926sAMYStriatum-like amygdalar nuclei1.806115388870241.50797879695892
21926STRStriatum3.105854272842412.17531156539917
21926STRdStriatum dorsal region1.629684090614321.17264580726624
21926STRvStriatum ventral region9.360453605651865.88177394866943
21926THThalamus2.216614246368411.69806826114655
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
7124GO:0005164TASFunctiontumor necrosis factor receptor binding
7124GO:0005515IPIFunctionprotein binding
7124GO:0005615IEAComponentextracellular space
7124GO:0005625TASComponentsoluble fraction
7124GO:0006355TASProcessregulation of transcription, DNA-dependent
7124GO:0006915TASProcessapoptosis
7124GO:0006916TASProcessanti-apoptosis
7124GO:0006955IEAProcessimmune response
7124GO:0007159TASProcessleukocyte adhesion
7124GO:0007165TASProcesssignal transduction
7124GO:0007267NRProcesscell-cell signaling
7124GO:0009611NRProcessresponse to wounding
7124GO:0009615TASProcessresponse to virus
7124GO:0016020IEAComponentmembrane
7124GO:0016021IEAComponentintegral to membrane
7124GO:0051092IDAProcessactivation of NF-kappaB transcription factor
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-7133NP_001057.1tumor necrosis factor receptor 2 precursorHPRD01862
NM_000594.28570NP_003676.1KH-type splicing regulatory protein (FUSE binding protein 2)BIND144435
NP_000585.17133-Tumor necrosis factor receptor 2HPRD01855
NP_000585.17124NP_000585.1tumor necrosis factor (cachectin)HPRD01855
NP_000585.17132NP_001056.1tumor necrosis factor receptor 1 precursorHPRD01855
NP_000585.17132NP_001056.1tumor necrosis factor receptor 1 precursorHPRD01861
NP_000585.27124NP_000585.2tumor necrosis factor alphaBIND261875
NP_000585.27124NP_000585.2tumor necrosis factor alphaBIND261874
NP_000585.27124NP_000585.2tumor necrosis factor alphaBIND261876
NP_000585.27132NP_001056.1tumor necrosis factor receptor 1 precursorBIND154040
NP_000585.27133NP_001057.1tumor necrosis factor receptor 2 precursorBIND154041
NP_000585.2155807NP_057852.2Vpr--
NP_000585.2155807NP_057852.2Vpr--
NP_000585.2155807NP_057852.2Vpr--
NP_000585.2155871NP_057853.1Tat--
NP_000585.2155871NP_057853.1Tat--
NP_000585.2155871NP_057853.1Tat--
NP_000585.2155871NP_057853.1Tat--
NP_000585.2155871NP_057853.1Tat--
NP_000585.2155871NP_057853.1Tat--
NP_000585.2155871NP_057853.1Tat--
NP_000585.2155871NP_057853.1Tat--
NP_000585.2155871NP_057853.1Tat--
NP_000585.2155871NP_057853.1Tat--
NP_000585.2155871NP_057853.1Tat--
NP_000585.2155871NP_057853.1Tat--
NP_000585.2155871NP_057853.1Tat--
NP_000585.2155030NP_579876.2matrix--
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
7124TNFA_HUMANP01375IPR006053TNF_abcTumor necrosis factor alpha, beta and c
7124TNFA_HUMANP01375IPR002959TNF_alphaTumour necrosis factor alpha/cachectin
7124TNFA_HUMANP01375IPR002960TNF_betaTumour necrosis factor beta/lymphotoxin alpha
7124TNFA_HUMANP01375IPR002961TNF_CTumour necrosis factor c/lymphotoxin-beta
7124TNFA_HUMANP01375IPR006052TNF_familyTumor Necrosis Factor

© Center for Bioinformatics(CBI), Peking University
Any Comments and suggestions to : KARG GROUP.