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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry

For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information Gene ID: 7157 Official Symbol: TP53 Other Aliases: LFS1|TRP53|p53 See related: HGNC:11998|MIM:191170|HPRD:01859 Chromosome: 17 Location: 17p13.1 Gene Description: tumor protein p53 (Li-Fraumeni syndrome) Gene type: protein-coding Gene Structure: Genomic Context: KARG Evidence 1 KARG ID: EVIM0234 ORGANISM: human Entrez Gene ID: 7157 Evidence Type: Microarray Evidence ID Type: PUBMED Evidence ID: 11093800 Addiction Drug: ALCOHOL Addiction Drug Detail: ALCOHOL ADMINISTRATION Addiction Brain Area: SH-SY5Y neuroblastoma cells Drug Effects: Downregulated Fold Change: At least 2-folds difference Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas) Mouse Entrez Gene ID Brain Region Brain Region Detail Expression Level Expression Density 22059 CB Cerebellum 11.524603843689 10.6075382232666 22059 CTX Cerebral cortex 24.0174770355225 12.7289876937866 22059 HIP Hippocampal region 6.74988842010498 4.34107732772827 22059 HPF Hippocampal formation 8.75684261322021 4.91025876998901 22059 HY Hypothalamus 10.2620887756348 4.7367205619812 22059 LSX Lateral septal complex 21.3933029174805 10.4213666915894 22059 MB Midbrain 5.91772222518921 4.70643091201782 22059 MY Medulla 16.3630981445312 12.1795701980591 22059 OLF Olfactory bulb 18.6278419494629 8.77362442016602 22059 P Pons 8.98217868804932 5.5160551071167 22059 PAL Pallidum 9.65355491638184 4.87069606781006 22059 RHP Retrohippocampal region 10.9102916717529 5.23059320449829 22059 sAMY Striatum-like amygdalar nuclei 9.98625946044922 4.92553234100342 22059 STR Striatum 8.16690158843994 4.20596170425415 22059 STRd Striatum dorsal region 4.63727712631226 2.5819776058197 22059 STRv Striatum ventral region 14.7567014694214 6.95968055725098 22059 TH Thalamus 10.468469619751 6.40827417373657 Gene Ontology Gene ID GO ID Evidence GO Type GO Description 7157 GO:0000075 TAS Process cell cycle checkpoint 7157 GO:0000739 IDA Function DNA strand annealing activity 7157 GO:0003700 IDA Function transcription factor activity 7157 GO:0003700 IEA Function transcription factor activity 7157 GO:0004518 TAS Function nuclease activity 7157 GO:0005507 IDA Function copper ion binding 7157 GO:0005515 IPI Function protein binding 7157 GO:0005524 IDA Function ATP binding 7157 GO:0005626 IDA Component insoluble fraction 7157 GO:0005634 IDA Component nucleus 7157 GO:0005634 IEA Component nucleus 7157 GO:0005654 IDA Component nucleoplasm 7157 GO:0005730 IDA Component nucleolus 7157 GO:0005739 IDA Component mitochondrion 7157 GO:0006284 TAS Process base-excision repair 7157 GO:0006289 IMP Process nucleotide-excision repair 7157 GO:0006310 TAS Process DNA recombination 7157 GO:0006350 IEA Process transcription 7157 GO:0006355 IDA Process regulation of transcription, DNA-dependent 7157 GO:0006355 IEA Process regulation of transcription, DNA-dependent 7157 GO:0006461 IDA Process protein complex assembly 7157 GO:0006915 IDA Process apoptosis 7157 GO:0007049 IEA Process cell cycle 7157 GO:0007050 TAS Process cell cycle arrest 7157 GO:0007569 IMP Process cell aging 7157 GO:0008270 TAS Function zinc ion binding 7157 GO:0008283 TAS Process cell proliferation 7157 GO:0008628 TAS Process induction of apoptosis by hormones 7157 GO:0008635 IDA Process caspase activation via cytochrome c 7157 GO:0016363 IDA Component nuclear matrix 7157 GO:0019899 IPI Function enzyme binding 7157 GO:0030154 TAS Process cell differentiation 7157 GO:0030308 IMP Process negative regulation of cell growth 7157 GO:0042771 IDA Process DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis 7157 GO:0046872 IEA Function metal ion binding 7157 GO:0046902 TAS Process regulation of mitochondrial membrane permeability 7157 GO:0046982 IPI Function protein heterodimerization activity 7157 GO:0047485 IPI Function protein N-terminus binding 7157 GO:0051097 TAS Process negative regulation of helicase activity 7157 GO:0051262 TAS Process protein tetramerization Interaction Information Gene Product ID Interactant Gene ID Interactant Gene Product ID Interactant Gene Product Name Source Source ID - 7337 NP_000453.2 ubiquitin protein ligase E3A isoform 2 HPRD 03375 - 7486 NP_000544.1 Werner syndrome protein HPRD 05212 - 7319 NP_003327.1 ubiquitin-conjugating enzyme E2A (RAD6 homolog) HPRD 02422 - 7329 NP_003336.1 ubiquitin-conjugating enzyme E2I HPRD 09045 - 7534 NP_003397.1 tyrosine 3/tryptophan 5 -monooxygenase activation protein, zeta polypeptide HPRD 03183 - 7874 NP_003461.1 ubiquitin specific protease 7 (herpes virus-associated) HPRD 03950 - 8575 NP_003681.1 protein kinase, interferon-inducible double stranded RNA dependent activator HPRD 04573 - 9232 NP_004210.1 pituitary tumor-transforming protein 1 HPRD 04998 - 9440 NP_004259.2 cofactor required for Sp1 transcriptional activation, subunit 6, 77kDa HPRD 04816 - 7158 NP_005648.1 tumor protein p53 binding protein, 1 HPRD 05569 - 26354 NP_055181.2 nucleostemin HPRD 06419 - 25898 NP_056251.1 ring finger and CHY zinc finger domain containing 1 HPRD 07607 - 51741 NP_057457.1 WW domain-containing oxidoreductase isoform 1 HPRD 05501 - 51246 NP_057563.3 scotin HPRD 06290 - 30008 NP_058634.1 EGF-containing fibulin-like extracellular matrix protein 2 HPRD 05221 - 26287 NP_065082.2 ankyrin repeat domain 2 HPRD 12460 - 7707 NP_068799.1 zinc finger protein 148 (pHZ-52) HPRD 03540 - 7490 NP_077744.2 Wilms tumor 1 isoform D HPRD 06163 - 94241 NP_150601.1 tumor protein p53 inducible nuclear protein 1 HPRD 09367 - 91768 NP_612384.1 Cdk5 and Abl enzyme substrate 1 HPRD 16461 - 91768 NP_612384.1 Cdk5 and Abl enzyme substrate 1 HPRD 16461 NP_000537.2 - - p95 HPRD 01859 NP_000537.2 - - TAFII31 HPRD 01859 NP_000537.2 - - TAFII60 HPRD 01859 NP_000537.2 - - p53BP2 HPRD 01859 NP_000537.2 - - UBE2I HPRD 01859 NP_000537.2 - - - BIND 296520 NP_000537.2 - - Cyclin H HPRD 01859 NP_000537.2 - - p53BP3 HPRD 01859 NP_000537.2 - - E1B-55K HPRD 01859 NP_000537.2 - - - BIND 181920 NP_000537.2 - - Zac1 HPRD 01859 NP_000537.2 - - AMF1 HPRD 01859 NP_000537.2 - - HSF3 HPRD 01859 NP_000537.2 - - S100A4 HPRD 01859 NP_000537.2 - - Interactor with cdk3 -1 HPRD 01859 NP_000537.2 - - RPA HPRD 01859 NP_000537.2 - - F-actin HPRD 01859 NP_000537.2 - - Topors HPRD 01859 NP_000537.2 - - - BIND 24869 NP_000537.2 - - NS5A HPRD 01859 NP_000537.2 - - E2FBP1 HPRD 01859 NP_000537.2 - - ING1b HPRD 01859 NP_000537.2 - - - BIND 183724 NP_000537.2 - - - BIND 183726 NP_000537.2 - - - BIND 185536 NP_000537.2 - - - BIND 257565 NP_000537.2 - AAB87527.2 Hepatitis C virus non-structural 5A protein (NS5A) gene, complete cds. BIND 182304 NP_000537.2 - AC091842.3 - BIND 258614 NP_000537.2 - AF411827.1 Homo sapiens BCL-2 binding component 3 (BBC3) gene, promoter and 5'UTR BIND 196726 NP_000537.2 - AP001132.4 Homo sapiens genomic DNA, chromosome 11q clone:RP11-712D22, complete sequences. BIND 258613 NP_000537.2 - NC_000002.9 Homo sapiens chromosome 2 BIND 257573 NP_000537.2 - NC_000002.9 Homo sapiens chromosome 2 BIND 257566 NP_000537.2 - NT_032977.6 Homo sapiens chromosome 1 genomic contig BIND 145629 NP_000537.2 - U24170.1 Human p21 (WAF1) gene, partial promoter sequence. BIND 183719 NP_000537.2 - U24170.1 Human p21 (WAF1) gene, partial promoter sequence. BIND 201896 NP_000537.2 - X63571.1 H.sapiens DNA binding motif recognized by p53 protein containing complexes BIND 296766 NP_000537.2 - Z85996.1 Human DNA sequence from clone RP3-431A14 on chromosome 6p21 Contains the CDKN1A gene for cyclin-dependent kinase inhibitor 1A, the gene for a novel protein similar to ras family protein, the gene for a novel copine-like protein (KIA1599), a galanin rec... BIND 194813 NP_000537.2 7158 - Tumor protein p53 binding protein 1 HPRD 01859 NP_000537.2 7490 - WT1 HPRD 01859 NP_000537.2 8575 - PKR protein activator HPRD 01859 NP_000537.2 7337 - Ubiquitin protein ligase E3A HPRD 01859 NP_000537.2 7534 - 14-3-3 zeta HPRD 01859 NP_000537.2 9440 - TRAP 80 HPRD 01859 NP_000537.2 30008 - Fibulin 4 HPRD 01859 NP_000537.2 51741 - WW domain containing oxidoreductase HPRD 01859 NP_000537.2 7707 - Zinc finger protein 148 HPRD 01859 NP_000537.2 7486 - RecQ protein like 2 HPRD 01859 NP_000537.2 94241 - P53DINP1 HPRD 01859 NP_000537.2 7874 - Ubiquitin specific protease 7 HPRD 01859 NP_000537.2 51246 - Scotin HPRD 01859 NP_000537.2 9232 - Pituitary tumor-transforming protein 1 HPRD 01859 NP_000537.2 26354 - Nucleostemin HPRD 01859 NP_000537.2 7319 - Ubiquitin conjugating enzyme E2A HPRD 01859 NP_000537.2 25898 - ARNIP HPRD 01859 NP_000537.2 51147 AAG43153.1 Homo sapiens brain my036 protein mRNA, complete cds. HPRD 09774 NP_000537.2 7159 CAC83012.1 ASPP2 protein HPRD 11803 NP_000537.2 9540 NC_000002.9 Homo sapiens chromosome 2 BIND 315955 NP_000537.2 8794 NC_000008.9 Homo sapiens chromosome 8, reference assembly BIND 218056 NP_000537.2 8795 NC_000008.9 Homo sapiens chromosome 8, reference assembly BIND 196727 NP_000537.2 9401 NC_000008.9 Homo sapiens chromosome 8, reference assembly BIND 217400 NP_000537.2 7157 NP_000537.2 tumor protein p53 BIND 196913 NP_000537.2 7157 NP_000537.2 tumor protein p53 BIND 215876 NP_000537.2 7157 NP_000537.2 tumor protein p53 BIND 315956 NP_000537.2 7486 NP_000544.1 Werner syndrome protein BIND 55314 NP_000537.2 7295 NP_003320.2 thioredoxin BIND 296744 NP_000537.2 7329 NP_003336.1 ubiquitin-conjugating enzyme E2I BIND 257578 NP_000537.2 7329 NP_003336.1 ubiquitin-conjugating enzyme E2I BIND 130935 NP_000537.2 7341 NP_003343.1 SMT3 suppressor of mif two 3 homolog 1 isoform a precursor BIND 130581 NP_000537.2 7528 NP_003394.1 YY1 transcription factor BIND 146442 NP_000537.2 7874 NP_003461.1 ubiquitin specific protease 7 (herpes virus-associated) BIND 295918 NP_000537.2 9232 NP_004210.1 pituitary tumor-transforming protein 1 BIND 57543 NP_000537.2 9112 NP_004680.1 metastasis associated protein HPRD 04633 NP_000537.2 9112 NP_004680.1 metastasis associated protein HPRD 01859 NP_000537.2 9219 NP_004730.2 metastasis-associated protein 2 BIND 181911 NP_000537.2 10055 NP_005491.1 SUMO-1 activating enzyme subunit 1 HPRD 18010 NP_000537.2 9013 NP_005670.2 TBP-associated factor 1C isoform 1 HPRD 01859 NP_000537.2 9013 NP_005670.2 TBP-associated factor 1C isoform 1 HPRD 05364 NP_000537.2 9014 NP_005671.1 TBP-associated factor 1B HPRD 01859 NP_000537.2 9014 NP_005671.1 TBP-associated factor 1B HPRD 05363 NP_000537.2 9015 NP_005672.1 TBP-associated factor 1A isoform 1 HPRD 01859 NP_000537.2 9015 NP_005672.1 TBP-associated factor 1A isoform 1 HPRD 05362 NP_000537.2 10153 NP_005751.2 CCAAT/enhancer binding protein zeta HPRD 09875 NP_000537.2 10153 NP_005751.2 CCAAT/enhancer binding protein zeta HPRD 01859 NP_000537.2 10210 NP_005793.2 topoisomerase I binding, arginine/serine-rich HPRD 11642 NP_000537.2 10210 NP_005793.2 topoisomerase I binding, arginine/serine-rich BIND 126458 NP_000537.2 7251 NP_006283.1 tumor susceptibility gene 101 HPRD 03229 NP_000537.2 7251 NP_006283.1 tumor susceptibility gene 101 HPRD 01859 NP_000537.2 10474 NP_006345.1 transcriptional adaptor 3-like isoform a HPRD 01859 NP_000537.2 10474 NP_006345.1 transcriptional adaptor 3-like isoform a HPRD 04252 NP_000537.2 8178 NP_006523.1 elongation factor RNA polymerase II HPRD 02615 NP_000537.2 8178 NP_006523.1 elongation factor RNA polymerase II HPRD 01859 NP_000537.2 10848 NP_006654.1 protein phosphatase 1, regulatory (inhibitor) subunit 13 like HPRD 01859 NP_000537.2 10848 NP_006654.1 protein phosphatase 1, regulatory (inhibitor) subunit 13 like BIND 193854 NP_000537.2 11244 NP_009153.2 zinc finger and homeodomain protein 1 HPRD 10379 NP_000537.2 23049 NP_054725.1 PI-3-kinase-related kinase SMG-1 isoform 2 BIND 144565 NP_000537.2 9656 NP_055456.1 mediator of DNA damage checkpoint 1 HPRD 16252 NP_000537.2 23113 NP_055904.1 p53-associated parkin-like cytoplasmic protein HPRD 01859 NP_000537.2 23113 NP_055904.1 p53-associated parkin-like cytoplasmic protein HPRD 06317 NP_000537.2 23113 NP_055904.1 p53-associated parkin-like cytoplasmic protein BIND 193853 NP_000537.2 25942 NP_056292.1 transcriptional co-repressor Sin3A BIND 128192 NP_000537.2 50484 NP_056528.2 ribonucleotide reductase M2 B (TP53 inducible) HPRD 05276 NP_000537.2 50484 NP_056528.2 ribonucleotide reductase M2 B (TP53 inducible) HPRD 01859 NP_000537.2 51147 NP_057246.2 inhibitor of growth family, member 4 BIND 130931 NP_000537.2 8554 NP_057250.1 protein inhibitor of activated STAT, 1 HPRD 16029 NP_000537.2 8554 NP_057250.1 protein inhibitor of activated STAT, 1 BIND 151010 NP_000537.2 64326 NP_071902.2 ring finger and WD repeat domain 2 isoform a BIND 133326 NP_000537.2 28996 NP_073577.2 homeodomain interacting protein kinase 2 BIND 13134 NP_000537.2 80854 NP_085151.1 SET domain-containing protein 7 HPRD 16226 NP_000537.2 81928 NP_112492.1 Cdk5 and Abl enzyme substrate 2 HPRD 12994 NP_000537.2 10075 NP_113584.3 HECT, UBA and WWE domain containing 1 BIND 314256 NP_000537.2 84289 NP_115705.2 inhibitor of growth family, member 5 HPRD 16348 NP_000537.2 84289 NP_115705.2 inhibitor of growth family, member 5 BIND 130927 NP_000537.2 8556 NP_201569.1 CDC14 homolog A isoform 2 HPRD 04614 NP_000537.2 8556 NP_201569.1 CDC14 homolog A isoform 2 HPRD 01859 NP_000537.2 8555 NP_201588.1 CDC14 homolog B isoform 2 HPRD 04615 NP_000537.2 8555 NP_201588.1 CDC14 homolog B isoform 2 HPRD 01859 NP_000537.2 54971 NP_524576.1 BTG3 associated nuclear protein isoform b HPRD 16538 NP_000537.2 204851 NP_938009.1 homeodomain-interacting protein kinase 1 isoform 1 HPRD 06418 NP_000537.2 204851 NP_938009.1 homeodomain-interacting protein kinase 1 isoform 1 HPRD 01859 NP_000537.2 10498 NP_954592.1 coactivator-associated arginine methyltransferase 1 BIND 145155 NP_000537.2 1489517 NP_043512.1 hypothetical protein Jvgp5 BIND 19164 NP_000537.2 1489531 NP_043127.1 large T antigen BIND 215090 NP_000537.2 1489531 NP_043127.1 large T antigen BIND 301706 NP_000537.2 951475 NP_751919.1 core protein BIND 180496 NP_000537.2 951475 NP_751919.1 core protein BIND 45602 NP_000537.2 951475 NP_751927.1 NS5A protein BIND 181843 NP_000537.2 951475 NP_751927.1 NS5A protein BIND 130446 NP_000537.2 951475 NP_803144.1 NS3 protease/helicase' BIND 193852 NP_000537.2 155807 NP_057852.2 Vpr - - NP_000537.2 155807 NP_057852.2 Vpr - - NP_000537.2 155807 NP_057852.2 Vpr - - NP_000537.2 155807 NP_057852.2 Vpr - - NP_000537.2 155871 NP_057853.1 Tat - - NP_000537.2 155871 NP_057853.1 Tat - - NP_000537.2 155871 NP_057853.1 Tat - - NP_000537.2 155871 NP_057853.1 Tat - - NP_000537.2 155871 NP_057853.1 Tat - - NP_000537.2 155871 NP_057853.1 Tat - - NP_000537.2 156110 NP_057857.2 Nef BIND 134417 NP_000537.2 1490008 NP_054373.1 nef protein BIND 134421 Domain Information Gene ID Uniprot/Swissprot ID Uniprot/Swissprot ACC Interpro ID Interpro Short Description Interpro Long Description 7157 P53_HUMAN P04637 IPR002117 P53 p53 tumor antigen 7157 P53_HUMAN P04637 IPR011615 P53_DNA_bd p53, DNA-binding 7157 P53_HUMAN P04637 IPR010991 p53_tetrameristn p53, tetramerisation 7157 P53_HUMAN P04637 IPR000694 PRO_rich Proline-rich region © Center for Bioinformatics(CBI), Peking University Any Comments and suggestions to : KARG GROUP.