Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:7157
Official Symbol:TP53
Other Aliases:LFS1|TRP53|p53
See related:HGNC:11998|MIM:191170|HPRD:01859
Chromosome:17
Location:17p13.1
Gene Description:tumor protein p53 (Li-Fraumeni syndrome)
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0234
ORGANISM:human
Entrez Gene ID:7157
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:11093800
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ADMINISTRATION
Addiction Brain Area:SH-SY5Y neuroblastoma cells
Drug Effects:Downregulated
Fold Change:At least 2-folds difference
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
22059CBCerebellum11.52460384368910.6075382232666
22059CTXCerebral cortex24.017477035522512.7289876937866
22059HIPHippocampal region6.749888420104984.34107732772827
22059HPFHippocampal formation8.756842613220214.91025876998901
22059HYHypothalamus10.26208877563484.7367205619812
22059LSXLateral septal complex21.393302917480510.4213666915894
22059MBMidbrain5.917722225189214.70643091201782
22059MYMedulla16.363098144531212.1795701980591
22059OLFOlfactory bulb18.62784194946298.77362442016602
22059PPons8.982178688049325.5160551071167
22059PALPallidum9.653554916381844.87069606781006
22059RHPRetrohippocampal region10.91029167175295.23059320449829
22059sAMYStriatum-like amygdalar nuclei9.986259460449224.92553234100342
22059STRStriatum8.166901588439944.20596170425415
22059STRdStriatum dorsal region4.637277126312262.5819776058197
22059STRvStriatum ventral region14.75670146942146.95968055725098
22059THThalamus10.4684696197516.40827417373657
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
7157GO:0000075TASProcesscell cycle checkpoint
7157GO:0000739IDAFunctionDNA strand annealing activity
7157GO:0003700IDAFunctiontranscription factor activity
7157GO:0003700IEAFunctiontranscription factor activity
7157GO:0004518TASFunctionnuclease activity
7157GO:0005507IDAFunctioncopper ion binding
7157GO:0005515IPIFunctionprotein binding
7157GO:0005524IDAFunctionATP binding
7157GO:0005626IDAComponentinsoluble fraction
7157GO:0005634IDAComponentnucleus
7157GO:0005634IEAComponentnucleus
7157GO:0005654IDAComponentnucleoplasm
7157GO:0005730IDAComponentnucleolus
7157GO:0005739IDAComponentmitochondrion
7157GO:0006284TASProcessbase-excision repair
7157GO:0006289IMPProcessnucleotide-excision repair
7157GO:0006310TASProcessDNA recombination
7157GO:0006350IEAProcesstranscription
7157GO:0006355IDAProcessregulation of transcription, DNA-dependent
7157GO:0006355IEAProcessregulation of transcription, DNA-dependent
7157GO:0006461IDAProcessprotein complex assembly
7157GO:0006915IDAProcessapoptosis
7157GO:0007049IEAProcesscell cycle
7157GO:0007050TASProcesscell cycle arrest
7157GO:0007569IMPProcesscell aging
7157GO:0008270TASFunctionzinc ion binding
7157GO:0008283TASProcesscell proliferation
7157GO:0008628TASProcessinduction of apoptosis by hormones
7157GO:0008635IDAProcesscaspase activation via cytochrome c
7157GO:0016363IDAComponentnuclear matrix
7157GO:0019899IPIFunctionenzyme binding
7157GO:0030154TASProcesscell differentiation
7157GO:0030308IMPProcessnegative regulation of cell growth
7157GO:0042771IDAProcessDNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis
7157GO:0046872IEAFunctionmetal ion binding
7157GO:0046902TASProcessregulation of mitochondrial membrane permeability
7157GO:0046982IPIFunctionprotein heterodimerization activity
7157GO:0047485IPIFunctionprotein N-terminus binding
7157GO:0051097TASProcessnegative regulation of helicase activity
7157GO:0051262TASProcessprotein tetramerization
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-7337NP_000453.2ubiquitin protein ligase E3A isoform 2HPRD03375
-7486NP_000544.1Werner syndrome proteinHPRD05212
-7319NP_003327.1ubiquitin-conjugating enzyme E2A (RAD6 homolog)HPRD02422
-7329NP_003336.1ubiquitin-conjugating enzyme E2IHPRD09045
-7534NP_003397.1tyrosine 3/tryptophan 5 -monooxygenase activation protein, zeta polypeptideHPRD03183
-7874NP_003461.1ubiquitin specific protease 7 (herpes virus-associated)HPRD03950
-8575NP_003681.1protein kinase, interferon-inducible double stranded RNA dependent activatorHPRD04573
-9232NP_004210.1pituitary tumor-transforming protein 1HPRD04998
-9440NP_004259.2cofactor required for Sp1 transcriptional activation, subunit 6, 77kDaHPRD04816
-7158NP_005648.1tumor protein p53 binding protein, 1HPRD05569
-26354NP_055181.2nucleosteminHPRD06419
-25898NP_056251.1ring finger and CHY zinc finger domain containing 1HPRD07607
-51741NP_057457.1WW domain-containing oxidoreductase isoform 1HPRD05501
-51246NP_057563.3scotinHPRD06290
-30008NP_058634.1EGF-containing fibulin-like extracellular matrix protein 2HPRD05221
-26287NP_065082.2ankyrin repeat domain 2HPRD12460
-7707NP_068799.1zinc finger protein 148 (pHZ-52)HPRD03540
-7490NP_077744.2Wilms tumor 1 isoform DHPRD06163
-94241NP_150601.1tumor protein p53 inducible nuclear protein 1HPRD09367
-91768NP_612384.1Cdk5 and Abl enzyme substrate 1HPRD16461
-91768NP_612384.1Cdk5 and Abl enzyme substrate 1HPRD16461
NP_000537.2--p95HPRD01859
NP_000537.2--TAFII31HPRD01859
NP_000537.2--TAFII60HPRD01859
NP_000537.2--p53BP2HPRD01859
NP_000537.2--UBE2IHPRD01859
NP_000537.2---BIND296520
NP_000537.2--Cyclin HHPRD01859
NP_000537.2--p53BP3HPRD01859
NP_000537.2--E1B-55KHPRD01859
NP_000537.2---BIND181920
NP_000537.2--Zac1HPRD01859
NP_000537.2--AMF1HPRD01859
NP_000537.2--HSF3HPRD01859
NP_000537.2--S100A4HPRD01859
NP_000537.2--Interactor with cdk3 -1HPRD01859
NP_000537.2--RPAHPRD01859
NP_000537.2--F-actinHPRD01859
NP_000537.2--ToporsHPRD01859
NP_000537.2---BIND24869
NP_000537.2--NS5AHPRD01859
NP_000537.2--E2FBP1HPRD01859
NP_000537.2--ING1bHPRD01859
NP_000537.2---BIND183724
NP_000537.2---BIND183726
NP_000537.2---BIND185536
NP_000537.2---BIND257565
NP_000537.2-AAB87527.2Hepatitis C virus non-structural 5A protein (NS5A) gene, complete cds.BIND182304
NP_000537.2-AC091842.3-BIND258614
NP_000537.2-AF411827.1Homo sapiens BCL-2 binding component 3 (BBC3) gene, promoter and 5'UTRBIND196726
NP_000537.2-AP001132.4Homo sapiens genomic DNA, chromosome 11q clone:RP11-712D22, complete sequences.BIND258613
NP_000537.2-NC_000002.9Homo sapiens chromosome 2BIND257573
NP_000537.2-NC_000002.9Homo sapiens chromosome 2BIND257566
NP_000537.2-NT_032977.6Homo sapiens chromosome 1 genomic contigBIND145629
NP_000537.2-U24170.1Human p21 (WAF1) gene, partial promoter sequence.BIND183719
NP_000537.2-U24170.1Human p21 (WAF1) gene, partial promoter sequence.BIND201896
NP_000537.2-X63571.1H.sapiens DNA binding motif recognized by p53 protein containing complexesBIND296766
NP_000537.2-Z85996.1Human DNA sequence from clone RP3-431A14 on chromosome 6p21 Contains the CDKN1A gene for cyclin-dependent kinase inhibitor 1A, the gene for a novel protein similar to ras family protein, the gene for a novel copine-like protein (KIA1599), a galanin rec...BIND194813
NP_000537.27158-Tumor protein p53 binding protein 1HPRD01859
NP_000537.27490-WT1HPRD01859
NP_000537.28575-PKR protein activatorHPRD01859
NP_000537.27337-Ubiquitin protein ligase E3AHPRD01859
NP_000537.27534-14-3-3 zetaHPRD01859
NP_000537.29440-TRAP 80HPRD01859
NP_000537.230008-Fibulin 4HPRD01859
NP_000537.251741-WW domain containing oxidoreductaseHPRD01859
NP_000537.27707-Zinc finger protein 148HPRD01859
NP_000537.27486-RecQ protein like 2HPRD01859
NP_000537.294241-P53DINP1HPRD01859
NP_000537.27874-Ubiquitin specific protease 7HPRD01859
NP_000537.251246-ScotinHPRD01859
NP_000537.29232-Pituitary tumor-transforming protein 1HPRD01859
NP_000537.226354-NucleosteminHPRD01859
NP_000537.27319-Ubiquitin conjugating enzyme E2AHPRD01859
NP_000537.225898-ARNIPHPRD01859
NP_000537.251147AAG43153.1Homo sapiens brain my036 protein mRNA, complete cds.HPRD09774
NP_000537.27159CAC83012.1ASPP2 proteinHPRD11803
NP_000537.29540NC_000002.9Homo sapiens chromosome 2BIND315955
NP_000537.28794NC_000008.9Homo sapiens chromosome 8, reference assemblyBIND218056
NP_000537.28795NC_000008.9Homo sapiens chromosome 8, reference assemblyBIND196727
NP_000537.29401NC_000008.9Homo sapiens chromosome 8, reference assemblyBIND217400
NP_000537.27157NP_000537.2tumor protein p53BIND196913
NP_000537.27157NP_000537.2tumor protein p53BIND215876
NP_000537.27157NP_000537.2tumor protein p53BIND315956
NP_000537.27486NP_000544.1Werner syndrome proteinBIND55314
NP_000537.27295NP_003320.2thioredoxinBIND296744
NP_000537.27329NP_003336.1ubiquitin-conjugating enzyme E2IBIND257578
NP_000537.27329NP_003336.1ubiquitin-conjugating enzyme E2IBIND130935
NP_000537.27341NP_003343.1SMT3 suppressor of mif two 3 homolog 1 isoform a precursorBIND130581
NP_000537.27528NP_003394.1YY1 transcription factorBIND146442
NP_000537.27874NP_003461.1ubiquitin specific protease 7 (herpes virus-associated)BIND295918
NP_000537.29232NP_004210.1pituitary tumor-transforming protein 1BIND57543
NP_000537.29112NP_004680.1metastasis associated proteinHPRD04633
NP_000537.29112NP_004680.1metastasis associated proteinHPRD01859
NP_000537.29219NP_004730.2metastasis-associated protein 2BIND181911
NP_000537.210055NP_005491.1SUMO-1 activating enzyme subunit 1HPRD18010
NP_000537.29013NP_005670.2TBP-associated factor 1C isoform 1HPRD01859
NP_000537.29013NP_005670.2TBP-associated factor 1C isoform 1HPRD05364
NP_000537.29014NP_005671.1TBP-associated factor 1BHPRD01859
NP_000537.29014NP_005671.1TBP-associated factor 1BHPRD05363
NP_000537.29015NP_005672.1TBP-associated factor 1A isoform 1HPRD01859
NP_000537.29015NP_005672.1TBP-associated factor 1A isoform 1HPRD05362
NP_000537.210153NP_005751.2CCAAT/enhancer binding protein zetaHPRD09875
NP_000537.210153NP_005751.2CCAAT/enhancer binding protein zetaHPRD01859
NP_000537.210210NP_005793.2topoisomerase I binding, arginine/serine-richHPRD11642
NP_000537.210210NP_005793.2topoisomerase I binding, arginine/serine-richBIND126458
NP_000537.27251NP_006283.1tumor susceptibility gene 101HPRD03229
NP_000537.27251NP_006283.1tumor susceptibility gene 101HPRD01859
NP_000537.210474NP_006345.1transcriptional adaptor 3-like isoform aHPRD01859
NP_000537.210474NP_006345.1transcriptional adaptor 3-like isoform aHPRD04252
NP_000537.28178NP_006523.1elongation factor RNA polymerase IIHPRD02615
NP_000537.28178NP_006523.1elongation factor RNA polymerase IIHPRD01859
NP_000537.210848NP_006654.1protein phosphatase 1, regulatory (inhibitor) subunit 13 likeHPRD01859
NP_000537.210848NP_006654.1protein phosphatase 1, regulatory (inhibitor) subunit 13 likeBIND193854
NP_000537.211244NP_009153.2zinc finger and homeodomain protein 1HPRD10379
NP_000537.223049NP_054725.1PI-3-kinase-related kinase SMG-1 isoform 2BIND144565
NP_000537.29656NP_055456.1mediator of DNA damage checkpoint 1HPRD16252
NP_000537.223113NP_055904.1p53-associated parkin-like cytoplasmic proteinHPRD01859
NP_000537.223113NP_055904.1p53-associated parkin-like cytoplasmic proteinHPRD06317
NP_000537.223113NP_055904.1p53-associated parkin-like cytoplasmic proteinBIND193853
NP_000537.225942NP_056292.1transcriptional co-repressor Sin3ABIND128192
NP_000537.250484NP_056528.2ribonucleotide reductase M2 B (TP53 inducible)HPRD05276
NP_000537.250484NP_056528.2ribonucleotide reductase M2 B (TP53 inducible)HPRD01859
NP_000537.251147NP_057246.2inhibitor of growth family, member 4BIND130931
NP_000537.28554NP_057250.1protein inhibitor of activated STAT, 1HPRD16029
NP_000537.28554NP_057250.1protein inhibitor of activated STAT, 1BIND151010
NP_000537.264326NP_071902.2ring finger and WD repeat domain 2 isoform aBIND133326
NP_000537.228996NP_073577.2homeodomain interacting protein kinase 2BIND13134
NP_000537.280854NP_085151.1SET domain-containing protein 7HPRD16226
NP_000537.281928NP_112492.1Cdk5 and Abl enzyme substrate 2HPRD12994
NP_000537.210075NP_113584.3HECT, UBA and WWE domain containing 1BIND314256
NP_000537.284289NP_115705.2inhibitor of growth family, member 5HPRD16348
NP_000537.284289NP_115705.2inhibitor of growth family, member 5BIND130927
NP_000537.28556NP_201569.1CDC14 homolog A isoform 2HPRD04614
NP_000537.28556NP_201569.1CDC14 homolog A isoform 2HPRD01859
NP_000537.28555NP_201588.1CDC14 homolog B isoform 2HPRD04615
NP_000537.28555NP_201588.1CDC14 homolog B isoform 2HPRD01859
NP_000537.254971NP_524576.1BTG3 associated nuclear protein isoform bHPRD16538
NP_000537.2204851NP_938009.1homeodomain-interacting protein kinase 1 isoform 1HPRD06418
NP_000537.2204851NP_938009.1homeodomain-interacting protein kinase 1 isoform 1HPRD01859
NP_000537.210498NP_954592.1coactivator-associated arginine methyltransferase 1BIND145155
NP_000537.21489517NP_043512.1hypothetical protein Jvgp5BIND19164
NP_000537.21489531NP_043127.1large T antigenBIND215090
NP_000537.21489531NP_043127.1large T antigenBIND301706
NP_000537.2951475NP_751919.1core proteinBIND180496
NP_000537.2951475NP_751919.1core proteinBIND45602
NP_000537.2951475NP_751927.1NS5A proteinBIND181843
NP_000537.2951475NP_751927.1NS5A proteinBIND130446
NP_000537.2951475NP_803144.1NS3 protease/helicase'BIND193852
NP_000537.2155807NP_057852.2Vpr--
NP_000537.2155807NP_057852.2Vpr--
NP_000537.2155807NP_057852.2Vpr--
NP_000537.2155807NP_057852.2Vpr--
NP_000537.2155871NP_057853.1Tat--
NP_000537.2155871NP_057853.1Tat--
NP_000537.2155871NP_057853.1Tat--
NP_000537.2155871NP_057853.1Tat--
NP_000537.2155871NP_057853.1Tat--
NP_000537.2155871NP_057853.1Tat--
NP_000537.2156110NP_057857.2NefBIND134417
NP_000537.21490008NP_054373.1nef proteinBIND134421
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
7157P53_HUMANP04637IPR002117P53p53 tumor antigen
7157P53_HUMANP04637IPR011615P53_DNA_bdp53, DNA-binding
7157P53_HUMANP04637IPR010991p53_tetrameristnp53, tetramerisation
7157P53_HUMANP04637IPR000694PRO_richProline-rich region

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