Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:7159
Official Symbol:TP53BP2
Other Aliases:53BP2|ASPP2|PPP1R13A
See related:HGNC:12000|MIM:602143|HPRD:11803
Chromosome:1
Location:1q42.1
Gene Description:tumor protein p53 binding protein, 2
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0887
ORGANISM:human
Entrez Gene ID:7159
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:11141048
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Downregulated
Fold Change:-1.4 :: -1.5 :: -1.3 :: -1
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
209456CBCerebellum4.804927349090586.33574676513672
209456CTXCerebral cortex3.422442436218262.47796320915222
209456HIPHippocampal region2.609265804290772.21826338768005
209456HPFHippocampal formation2.829961299896242.54561305046082
209456HYHypothalamus2.192012548446661.54238486289978
209456LSXLateral septal complex1.408911943435671.15848112106323
209456MBMidbrain3.04151415824892.6581768989563
209456MYMedulla8.417233467102059.35405921936035
209456OLFOlfactory bulb21.118965148925816.1533031463623
209456PPons5.031867980957034.9002537727356
209456PALPallidum2.346709012985231.70800805091858
209456RHPRetrohippocampal region3.206795454025273.00098371505737
209456sAMYStriatum-like amygdalar nuclei2.579885721206672.58462762832642
209456STRStriatum2.064409971237181.70517146587372
209456STRdStriatum dorsal region2.261655092239381.9451242685318
209456STRvStriatum ventral region1.408256292343140.792517423629761
209456THThalamus2.655889987945562.23516225814819
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
7159GO:0005070TASFunctionSH3/SH2 adaptor activity
7159GO:0005515IPIFunctionprotein binding
7159GO:0005737TASComponentcytoplasm
7159GO:0006915IEAProcessapoptosis
7159GO:0006917IDAProcessinduction of apoptosis
7159GO:0007049IEAProcesscell cycle
7159GO:0007165TASProcesssignal transduction
7159GO:0045786TASProcessnegative regulation of progression through cell cycle
7159GO:0051059IPIFunctionNF-kappaB binding
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
CAC83012.1-AAR06173.1Hepatitis C virus core gene, complete cdsBIND180545
CAC83012.17525-c-YesHPRD11803
CAC83012.19223NP_004733.1BAI1-associated protein 1HPRD11803
CAC83012.110413NP_006097.1Yes-associated protein 1, 65 kDHPRD11803
CAC83012.111059NP_008944.1WW domain containing E3 ubiquitin protein ligase 1HPRD11803
CAC83012.111060NP_008945.1Nedd-4-like ubiquitin-protein ligaseHPRD11803
CAC83012.111060NP_008945.1Nedd-4-like ubiquitin-protein ligaseHPRD03812
NP_005417.18883NP_003896.1amyloid beta precursor protein-binding protein 1 isoform aBIND19167
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
7159IPR002110ANKAnkyrin
7159IPR000694PRO_richProline-rich region
7159IPR001452SH3Src homology-3
7159IPR011511SH3_2Variant SH3
7159IPR013555TRP_2Transient receptor ion channel II
7159ASPP2_HUMANQ13625IPR002110ANKAnkyrin
7159ASPP2_HUMANQ13625IPR000694PRO_richProline-rich region
7159ASPP2_HUMANQ13625IPR001452SH3Src homology-3
7159ASPP2_HUMANQ13625IPR011511SH3_2Variant SH3
7159ASPP2_HUMANQ13625IPR013555TRP_2Transient receptor ion channel II

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