Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:7166
Official Symbol:TPH1
Other Aliases:MGC119994|TPH|TPRH
See related:HGNC:12008|MIM:191060|HPRD:01846
Chromosome:11
Location:11p15.3-p14
Gene Description:tryptophan hydroxylase 1 (tryptophan 5-monooxygenase)
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIL0146
ORGANISM:human
Entrez Gene ID:7166
Evidence Type:LT Reports
Evidence ID Type:PUBMED
Evidence ID:15635702
Addiction Drug:NICOTINE
Addiction Drug Detail:NICOTINE ABUSE
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
21990CBCerebellum0.4251896739006040.738559424877167
21990CTXCerebral cortex0.296782761812210.407012969255447
21990HIPHippocampal region0.08662482351064680.125686675310135
21990HPFHippocampal formation0.09876799583435060.117263577878475
21990HYHypothalamus0.1787694096565250.144781827926636
21990LSXLateral septal complex0.2043859362602230.460490494966507
21990MBMidbrain0.2420862615108490.299231678247452
21990MYMedulla0.3182345926761630.503381192684174
21990OLFOlfactory bulb0.3533562123775480.973098397254944
21990PPons0.1938513368368150.257220834493637
21990PALPallidum0.1127727925777440.123562090098858
21990RHPRetrohippocampal region0.1262275427579880.113848261535168
21990sAMYStriatum-like amygdalar nuclei0.04034171998500820.0
21990STRStriatum0.27916881442070.272411376237869
21990STRdStriatum dorsal region0.3304293155670170.313165038824081
21990STRvStriatum ventral region0.2822393774986270.203119918704033
21990THThalamus0.2783251702785490.298283725976944
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
7166GO:0004497IEAFunctionmonooxygenase activity
7166GO:0004510IEAFunctiontryptophan 5-monooxygenase activity
7166GO:0005506IEAFunctioniron ion binding
7166GO:0006587IEAProcessserotonin biosynthesis from tryptophan
7166GO:0008152IEAProcessmetabolism
7166GO:0016597IEAFunctionamino acid binding
7166GO:0046872IEAFunctionmetal ion binding
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-7534NP_003397.1tyrosine 3/tryptophan 5 -monooxygenase activation protein, zeta polypeptideHPRD03183
NP_004170.17534-14-3-3 zetaHPRD01846
NP_004170.17533NP_003396.1tyrosine 3/tryptophan 5 -monooxygenase activation protein, eta polypeptideHPRD01846
NP_004170.17533NP_003396.1tyrosine 3/tryptophan 5 -monooxygenase activation protein, eta polypeptideHPRD00215
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
7166TPH1_HUMANP17752IPR001273Aaa_hydroxylaseAromatic amino acid hydroxylase
7166TPH1_HUMANP17752IPR002912ACT_bdAmino acid-binding ACT

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