Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:7169
Official Symbol:TPM2
Other Aliases:AMCD1|DA1|TMSB
See related:HGNC:12011|MIM:190990|HPRD:11768
Chromosome:9
Location:9p13.2-p13.1
Gene Description:tropomyosin 2 (beta)
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIP0210
ORGANISM:human
Entrez Gene ID:7169
Evidence Type:Proteomics
Evidence ID Type:PUBMED
Evidence ID:15542695
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Whole Brain
Drug Effects:Downregulated
Fold Change:0.47
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
22004CBCerebellum21.752559661865235.4111518859863
22004CTXCerebral cortex1.765962839126591.63031733036041
22004HIPHippocampal region2.852211236953743.21466493606567
22004HPFHippocampal formation2.867924928665162.87173628807068
22004HYHypothalamus0.2157883793115620.341824471950531
22004LSXLateral septal complex0.2714410126209260.290146499872208
22004MBMidbrain0.8646092414855961.46580994129181
22004MYMedulla2.701419353485113.58965635299683
22004OLFOlfactory bulb5.02447795867923.73684334754944
22004PPons0.6666333675384521.00205755233765
22004PALPallidum0.1568809598684310.132664620876312
22004RHPRetrohippocampal region2.88983321189882.42391037940979
22004sAMYStriatum-like amygdalar nuclei0.7644305825233460.770611166954041
22004STRStriatum1.277667880058291.10186874866486
22004STRdStriatum dorsal region1.739703059196471.48876190185547
22004STRvStriatum ventral region0.8141710162162780.648241877555847
22004THThalamus0.5517421960830690.649955034255981
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
7169GO:0003779IEAFunctionactin binding
7169GO:0005856IEAComponentcytoskeleton
7169GO:0005862TASComponentmuscle thin filament tropomyosin
7169GO:0008307TASFunctionstructural constituent of muscle
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-9260NP_005442.2PDZ and LIM domain 7 isoform 1HPRD10436
NP_003280.29260-EnigmaHPRD11768
NP_003280.27169NP_003280.2tropomyosin 2 (beta) isoform 1HPRD11768
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
7169IPR008374SF_assemblinSF_assemblin
7169IPR002017SpectrinSpectrin repeat
7169IPR000956StathminStathmin
7169IPR000533TropomyosinTropomyosin
7169TPM2_HUMANP07951IPR005827KCNQ1_channelKCNQ1 voltage-gated potassium channel
7169TPM2_HUMANP07951IPR008374SF_assemblinSF_assemblin
7169TPM2_HUMANP07951IPR002017SpectrinSpectrin repeat
7169TPM2_HUMANP07951IPR000956StathminStathmin
7169TPM2_HUMANP07951IPR000533TropomyosinTropomyosin

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