Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:7277
Official Symbol:TUBA1
Other Aliases:FLJ30169|H2-ALPHA
See related:HGNC:12407|MIM:191110|HPRD:01851
Chromosome:2
Location:2q35
Gene Description:tubulin, alpha 1 (testis specific)
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0106
ORGANISM:human
Entrez Gene ID:7277
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12629581
Addiction Drug:COCAINE
Addiction Drug Detail:COCAINE ABUSE
Addiction Brain Area:Dorsolateral Prefrontal Cortex
Drug Effects:Upregulated/Downregulated
Fold Change:3.57 :: 3.73 :: 1.86 :: 0.45 :: -3.27 :: -3.72 :: -3.78
KARG Evidence 2
KARG ID:EVIM0344
ORGANISM:human
Entrez Gene ID:7277
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:15816859
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Nucleus Accumbens
Drug Effects:Downregulated
Fold Change:-0.67
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
22145CBCerebellum47.937438964843876.0659694671631
22145CTXCerebral cortex100.0100.0
22145HIPHippocampal region100.0100.0
22145HPFHippocampal formation100.0100.0
22145HYHypothalamus79.463935852050894.7651824951172
22145LSXLateral septal complex100.0100.0
22145MBMidbrain78.360210418701294.1418190002441
22145MYMedulla61.274240493774494.3957710266113
22145OLFOlfactory bulb100.0100.0
22145PPons68.222454071044999.7822647094727
22145PALPallidum81.9365348815918100.0
22145RHPRetrohippocampal region100.0100.0
22145sAMYStriatum-like amygdalar nuclei97.4819297790527100.0
22145STRStriatum100.0100.0
22145STRdStriatum dorsal region100.0100.0
22145STRvStriatum ventral region96.954753875732487.1906776428223
22145THThalamus88.9731292724609100.0
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
7277GO:0000166IEAFunctionnucleotide binding
7277GO:0003924IEAFunctionGTPase activity
7277GO:0005198IEAFunctionstructural molecule activity
7277GO:0005515IPIFunctionprotein binding
7277GO:0005525IEAFunctionGTP binding
7277GO:0005874IEAComponentmicrotubule
7277GO:0007018IEAProcessmicrotubule-based movement
7277GO:0043234IEAComponentprotein complex
7277GO:0051258IEAProcessprotein polymerization
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-29127NP_037409.2Rac GTPase activating protein 1HPRD05402
-51604NP_057021.2phosphatidylinositol glycan, class T precursorHPRD15136
-51762NP_057614.1RAB8B, member RAS oncogene familyHPRD11476
NP_005991.1--c-cpnHPRD01851
NP_005991.17535-ZAP70HPRD01851
NP_005991.129127-RAC GTPase activating protein 1HPRD01851
NP_005991.19344NP_057235.2TAO kinase 2 isoform 2HPRD18147
NP_005991.190627NP_821074.1START domain containing 13 isoform alphaHPRD11607
NP_005991.1155871NP_057853.1Tat--
NP_005991.1155908NP_057854.1Rev--
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
7277TBA1_HUMANP68366IPR002452Alpha_tubulinAlpha tubulin
7277TBA1_HUMANP68366IPR002453Beta_tubulinBeta tubulin
7277TBA1_HUMANP68366IPR002967Delta_tubulinDelta tubulin
7277TBA1_HUMANP68366IPR004057Epsilon_tubulinEpsilon tubulin
7277TBA1_HUMANP68366IPR000158FtsZCell division protein FtsZ
7277TBA1_HUMANP68366IPR002454Gamma_tubulinGamma tubulin
7277TBA1_HUMANP68366IPR000217TubulinTubulin
7277TBA1_HUMANP68366IPR003008Tubulin_FtsZTubulin/FtsZ, GTPase
7277TBA1_HUMANP68366IPR008280Tub_FtsZ_CTubulin/FtsZ, C-terminal

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