Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:7278
Official Symbol:TUBA2
Other Aliases:bA408E5.3
See related:HGNC:12408|MIM:602528|HPRD:03958
Chromosome:13
Location:13q11
Gene Description:tubulin, alpha 2
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0108
ORGANISM:human
Entrez Gene ID:7278
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12629581
Addiction Drug:COCAINE
Addiction Drug Detail:COCAINE ABUSE
Addiction Brain Area:Dorsolateral Prefrontal Cortex
Drug Effects:Upregulated/Downregulated
Fold Change:2.82 :: 3.59 :: 2.14 :: 0.87 :: -4.13 :: -3.60 :: -4.98
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
7278GO:0000166IEAFunctionnucleotide binding
7278GO:0003924IEAFunctionGTPase activity
7278GO:0005198IEAFunctionstructural molecule activity
7278GO:0005515IPIFunctionprotein binding
7278GO:0005525NASFunctionGTP binding
7278GO:0005874NASComponentmicrotubule
7278GO:0007018IEAProcessmicrotubule-based movement
7278GO:0043234IEAComponentprotein complex
7278GO:0051258IEAProcessprotein polymerization
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-7283NP_001061.1tubulin, gamma 1HPRD01853
-8655NP_003737.1dynein light chain 1HPRD03334
NP_005992.1--Prefoldin 5HPRD03958
NP_005992.1--MAP3K1HPRD03958
NP_005992.17283-Tubulin gamma 1HPRD03958
NP_005992.18655-DLC1HPRD03958
NP_005992.18655-Dynein light chain 1HPRD03958
NP_005992.18517NP_003630.1inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gammaHPRD03958
NP_005992.18717NP_003780.1TNFRSF1A-associated via death domain isoform 1HPRD04610
NP_005992.18717NP_003780.1TNFRSF1A-associated via death domain isoform 1HPRD03958
NP_005992.18737NP_003795.1receptor (TNFRSF)-interacting serine-threonine kinase 1HPRD03958
NP_005992.18767NP_003812.1receptor-interacting serine-threonine kinase 2HPRD03958
NP_005992.19020NP_003945.1mitogen-activated protein kinase kinase kinase 14HPRD03958
NP_005992.110010NP_004171.2TRAF interacting protein TANK isoform aHPRD03958
NP_005992.110454NP_006107.1mitogen-activated protein kinase kinase kinase 7 interacting protein 1 isoform alphaHPRD03958
NP_005992.110971NP_006817.1tyrosine 3/tryptophan 5 -monooxygenase activation protein, theta polypeptideHPRD03958
NP_005992.111035NP_006862.2receptor-interacting serine-threonine kinase 3HPRD03958
NP_005992.129110NP_037386.1TANK-binding kinase 1HPRD03958
NP_005992.19641NP_054721.1IKK-related kinase epsilonHPRD03958
NP_005992.123118NP_055908.1mitogen-activated protein kinase kinase kinase 7 interacting protein 2HPRD03958
NP_005992.123118NP_055908.1mitogen-activated protein kinase kinase kinase 7 interacting protein 2HPRD05483
NP_005992.1155871NP_057853.1Tat--
NP_005992.1155908NP_057854.1Rev--
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
7278IPR002452Alpha_tubulinAlpha tubulin
7278IPR002453Beta_tubulinBeta tubulin
7278IPR002967Delta_tubulinDelta tubulin
7278IPR004057Epsilon_tubulinEpsilon tubulin
7278IPR000158FtsZCell division protein FtsZ
7278IPR002454Gamma_tubulinGamma tubulin
7278IPR000217TubulinTubulin
7278IPR003008Tubulin_FtsZTubulin/FtsZ, GTPase
7278IPR008280Tub_FtsZ_CTubulin/FtsZ, C-terminal
7278TBA2_HUMANQ13748IPR002452Alpha_tubulinAlpha tubulin
7278TBA2_HUMANQ13748IPR002453Beta_tubulinBeta tubulin
7278TBA2_HUMANQ13748IPR002967Delta_tubulinDelta tubulin
7278TBA2_HUMANQ13748IPR004057Epsilon_tubulinEpsilon tubulin
7278TBA2_HUMANQ13748IPR000158FtsZCell division protein FtsZ
7278TBA2_HUMANQ13748IPR002454Gamma_tubulinGamma tubulin
7278TBA2_HUMANQ13748IPR000217TubulinTubulin
7278TBA2_HUMANQ13748IPR003008Tubulin_FtsZTubulin/FtsZ, GTPase
7278TBA2_HUMANQ13748IPR008280Tub_FtsZ_CTubulin/FtsZ, C-terminal

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