Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:7295
Official Symbol:TXN
Other Aliases:DKFZp686B1993|MGC61975|TRX
See related:HGNC:12435|MIM:187700|HPRD:01761
Chromosome:9
Location:9q31
Gene Description:thioredoxin
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0303
ORGANISM:human
Entrez Gene ID:7295
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:15816859
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Prefrontal Cortex
Drug Effects:Upregulated
Fold Change:0.58
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
22166CBCerebellum0.00.0
22166CTXCerebral cortex0.00.0
22166HIPHippocampal region0.00.0
22166HPFHippocampal formation0.00.0
22166HYHypothalamus0.00.0
22166LSXLateral septal complex0.00.0
22166MBMidbrain0.00.0
22166MYMedulla0.00.0
22166OLFOlfactory bulb0.00.0
22166PPons0.00.0
22166PALPallidum0.00.0
22166RHPRetrohippocampal region0.00.0
22166sAMYStriatum-like amygdalar nuclei0.00.0
22166STRStriatum0.00.0
22166STRdStriatum dorsal region0.00.0
22166STRvStriatum ventral region0.00.0
22166THThalamus0.00.0
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
7295GO:0005515IPIFunctionprotein binding
7295GO:0006118IEAProcesselectron transport
7295GO:0006928TASProcesscell motility
7295GO:0007165TASProcesssignal transduction
7295GO:0007267TASProcesscell-cell signaling
7295GO:0008283TASProcesscell proliferation
7295GO:0030508TASFunctionthiol-disulfide exchange intermediate activity
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
NP_003320.1--CP-pro alpha, 1(1)HPRD01761
NP_003320.110628NP_006463.2thioredoxin interacting proteinHPRD01761
NP_003320.110628NP_006463.2thioredoxin interacting proteinHPRD05964
NP_003320.210628NP_006463.2thioredoxin interacting proteinBIND217503
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
7295THIO_HUMANP10599IPR002109GlutaredoxinGlutaredoxin
7295THIO_HUMANP10599IPR006662ThioredThioredoxin-related
7295THIO_HUMANP10599IPR013766Thioredoxin_domThioredoxin domain
7295THIO_HUMANP10599IPR006663Thioredox_dom2Thioredoxin domain 2

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