Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:7329
Official Symbol:UBE2I
Other Aliases:C358B7.1|P18|UBC9
See related:HGNC:12485|MIM:601661|HPRD:09045
Chromosome:16
Location:16p13.3
Gene Description:ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0153
ORGANISM:human
Entrez Gene ID:7329
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12629581
Addiction Drug:COCAINE
Addiction Drug Detail:COCAINE ABUSE
Addiction Brain Area:Dorsolateral Prefrontal Cortex
Drug Effects:Upregulated/Downregulated
Fold Change:-2.24 :: -1.32 :: -1.05 :: -1.40 :: 0.99 :: 1.29 :: 1.33
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
22196CBCerebellum0.8096456527709961.24576723575592
22196CTXCerebral cortex2.011423110961911.72689282894135
22196HIPHippocampal region4.56977176666264.14342641830444
22196HPFHippocampal formation3.536989212036133.06456542015076
22196HYHypothalamus0.1380417048931120.137275010347366
22196LSXLateral septal complex0.01702582836151120.0
22196MBMidbrain0.3900227844715120.737363934516907
22196MYMedulla0.1298370510339740.218666717410088
22196OLFOlfactory bulb0.7305729985237120.786493062973022
22196PPons0.353870481252670.700364947319031
22196PALPallidum0.06147022545337680.0942926481366158
22196RHPRetrohippocampal region1.936024665832521.64645075798035
22196sAMYStriatum-like amygdalar nuclei1.268197417259221.48018479347229
22196STRStriatum0.2744905352592470.329141318798065
22196STRdStriatum dorsal region0.099135197699070.146821230649948
22196STRvStriatum ventral region0.3576015532016750.346863895654678
22196THThalamus0.3620729744434360.349671185016632
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
7329GO:0004842IEAFunctionubiquitin-protein ligase activity
7329GO:0005515IPIFunctionprotein binding
7329GO:0006512IEAProcessubiquitin cycle
7329GO:0016874IEAFunctionligase activity
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-7341NP_003343.1SMT3 suppressor of mif two 3 homolog 1 isoform a precursorHPRD03554
-333926NP_005158.4protein phosphatase 2a, catalytic subunit, zeta isoformHPRD15171
NP_003336.1--RAD52HPRD09045
NP_003336.1--MAP3K1HPRD09045
NP_003336.1--DACHHPRD09045
NP_003336.1--STRA13HPRD09045
NP_003336.1--GMEB1HPRD09045
NP_003336.1--GMEB2HPRD09045
NP_003336.1--PIASxalphaHPRD09045
NP_003336.1--Nfi1HPRD09045
NP_003336.1--SAE1HPRD09045
NP_003336.1--histone H4HPRD09045
NP_003336.1-P17881Nucleocapsid protein (Nucleoprotein).BIND57966
NP_003336.17341-SUMO1HPRD09045
NP_003336.18535AAB80718.1Homo sapiens Polycomb 2 homolog (hPc2) mRNA, complete cds.BIND196977
NP_003336.17341NP_003343.1SMT3 suppressor of mif two 3 homolog 1 isoform a precursorBIND134413
NP_003336.17341NP_003343.1SMT3 suppressor of mif two 3 homolog 1 isoform a precursorBIND196918
NP_003336.19063NP_004662.1protein inhibitor of activated STAT X isoform betaBIND145516
NP_003336.110210NP_005793.2topoisomerase I binding, arginine/serine-richHPRD11642
NP_003336.19670NP_055467.2importin 13HPRD13742
NP_003336.18554NP_057250.1protein inhibitor of activated STAT, 1HPRD16029
NP_003336.18554NP_057250.1protein inhibitor of activated STAT, 1BIND57965
NP_003336.151567NP_057698.2TRAF and TNF receptor-associated proteinBIND58140
NP_003336.128996NP_073577.1homeodomain interacting protein kinase 2HPRD09045
NP_003336.128996NP_073577.2homeodomain interacting protein kinase 2BIND145515
NP_003336.17490NP_077744.2Wilms tumor 1 isoform DHPRD09045
NP_003336.12943078NP_941977.1nucleocapsid proteinBIND123344
NP_003336.11489075NP_041327.1replication proteinBIND151928
NP_919237.19618NP_004286.2TNF receptor-associated factor 4 isoform 1BIND151762
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
7329UBE2I_HUMANP63279IPR000608UBQ-conjugat_E2Ubiquitin-conjugating enzyme, E2

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