Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:7334
Official Symbol:UBE2N
Other Aliases:MGC131857|MGC8489|UBC13|UbcH-ben
See related:HGNC:12492|MIM:603679|HPRD:04725
Chromosome:12
Location:12q22
Gene Description:ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast)
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0156
ORGANISM:human
Entrez Gene ID:7334
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12629581
Addiction Drug:COCAINE
Addiction Drug Detail:COCAINE ABUSE
Addiction Brain Area:Dorsolateral Prefrontal Cortex
Drug Effects:Upregulated/Downregulated
Fold Change:2.68 :: 1.99 :: 2.21 :: 1.31 :: -1.25 :: -1.95 :: 2.10
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
7334GO:0004842IEAFunctionubiquitin-protein ligase activity
7334GO:0005515IPIFunctionprotein binding
7334GO:0006512IEAProcessubiquitin cycle
7334GO:0016874IEAFunctionligase activity
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-387522NP_003340.1ubiquitin-conjugating enzyme E2 Kua-UEV isoform 2HPRD04294
-7336NP_003341.1ubiquitin-conjugating enzyme E2 variant 2HPRD04300
NP_003339.1387522-Ubiquitin conjugating enzyme E2 variant 1HPRD04725
NP_003339.17336-Ubiquitin conjugating enzyme E2 variant 2HPRD04725
NP_003339.18915NP_003912.1B-cell CLL/lymphoma 10BIND55262
NP_003339.1387522NP_954673.1ubiquitin-conjugating enzyme E2 Kua-UEV isoform 1HPRD11926
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
7334UBE2N_HUMANP61088IPR000608UBQ-conjugat_E2Ubiquitin-conjugating enzyme, E2

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