Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:7345
Official Symbol:UCHL1
Other Aliases:PARK5|PGP9.5
See related:HGNC:12513|MIM:191342|HPRD:01877
Chromosome:4
Location:4p14
Gene Description:ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0402
ORGANISM:human
Entrez Gene ID:7345
Evidence Type:Mapping from rat
Evidence ID Type:Entrez Gene
Evidence ID:29545
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 2
KARG ID:EVIM0152
ORGANISM:human
Entrez Gene ID:7345
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12629581
Addiction Drug:COCAINE
Addiction Drug Detail:COCAINE ABUSE
Addiction Brain Area:Dorsolateral Prefrontal Cortex
Drug Effects:Upregulated/Downregulated
Fold Change:4.32 :: 4.70 :: 5.11 :: 2.63 :: -2.94 :: -3.71 :: -0.48
KARG Evidence 3
KARG ID:EVIP0216
ORGANISM:human
Entrez Gene ID:7345
Evidence Type:Proteomics
Evidence ID Type:PUBMED
Evidence ID:15542695
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Whole Brain
Drug Effects:Downregulated
Fold Change:0.35
KARG Evidence 4
KARG ID:EVIP0261
ORGANISM:human
Entrez Gene ID:7345
Evidence Type:Proteomics
Evidence ID Type:PUBMED
Evidence ID:16172612
Addiction Drug:ALCOHOL
Addiction Drug Detail:Chronic alcohol use
Addiction Brain Area:Brain
Drug Effects:Downregulated
Fold Change:-1.1::-1.2
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
22223CBCerebellum30.392894426981665.1686223347982
22223CTXCerebral cortex100.0100.0
22223HIPHippocampal region100.0100.0
22223HPFHippocampal formation100.0100.0
22223HYHypothalamus100.0100.0
22223LSXLateral septal complex100.0100.0
22223MBMidbrain96.2083536783854100.0
22223MYMedulla75.688730239868289.1283569335938
22223OLFOlfactory bulb100.0100.0
22223PPons84.4413274129232100.0
22223PALPallidum100.0100.0
22223RHPRetrohippocampal region100.0100.0
22223sAMYStriatum-like amygdalar nuclei100.0100.0
22223STRStriatum100.0100.0
22223STRdStriatum dorsal region100.0100.0
22223STRvStriatum ventral region100.0100.0
22223THThalamus100.0100.0
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
7345GO:0004197IDAFunctioncysteine-type endopeptidase activity
7345GO:0004221TASFunctionubiquitin thiolesterase activity
7345GO:0005737ISSComponentcytoplasm
7345GO:0005737TASComponentcytoplasm
7345GO:0006511IEAProcessubiquitin-dependent protein catabolism
7345GO:0008242IDAFunctionomega peptidase activity
7345GO:0016579IDAProcessprotein deubiquitination
7345GO:0016874IEAFunctionligase activity
7345GO:0043130IDAFunctionubiquitin binding
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-10048NP_005484.1RAN binding protein 9HPRD04835
-10987NP_006828.2COP9 signalosome subunit 5HPRD06888
NP_004172.2--UBC9HPRD01877
NP_004172.210048-RAN binding protein 9HPRD01877
NP_004172.210987-COP9, subunit 5HPRD01877
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
7345UCHL1_HUMANP09936IPR001578Peptidase_C12Peptidase C12, ubiquitin carboxyl-terminal hydrolase 1

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