Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:7368
Official Symbol:UGT8
Other Aliases:CGT
See related:HGNC:12555|MIM:601291|HPRD:03186
Chromosome:4
Location:4q26
Gene Description:UDP glycosyltransferase 8 (UDP-galactose ceramide galactosyltransferase)
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0836
ORGANISM:human
Entrez Gene ID:7368
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:11141048
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Downregulated
Fold Change:-1 :: -1.4 :: -1.9 :: -1.7
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
22239CBCerebellum22.373722553253224.5016412734985
22239CTXCerebral cortex22.405497908592217.5751546621323
22239HIPHippocampal region18.230547666549718.5255072116852
22239HPFHippocampal formation19.62049925327318.3666021823883
22239HYHypothalamus24.002384781837518.4553483724594
22239LSXLateral septal complex30.292802333831823.0190658569336
22239MBMidbrain36.349293708801331.583279132843
22239MYMedulla48.519203186035247.0947780609131
22239OLFOlfactory bulb29.877333641052223.0649015903473
22239PPons50.3919119834946.7500948905945
22239PALPallidum26.384565591812123.3673371076584
22239RHPRetrohippocampal region21.057571530342117.6098779439926
22239sAMYStriatum-like amygdalar nuclei21.333708286285416.0278829932213
22239STRStriatum22.361455440521217.4992349147797
22239STRdStriatum dorsal region24.201311111450219.7689905166626
22239STRvStriatum ventral region15.55599176883710.8362227678299
22239THThalamus30.260295152664224.5000700950623
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
7368GO:0003851IEAFunction2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity
7368GO:0005783IEAComponentendoplasmic reticulum
7368GO:0005792IEAComponentmicrosome
7368GO:0006688NRProcessglycosphingolipid biosynthesis
7368GO:0007417TASProcesscentral nervous system development
7368GO:0007422TASProcessperipheral nervous system development
7368GO:0008152IEAProcessmetabolism
7368GO:0008489TASFunctionUDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity
7368GO:0016020IEAComponentmembrane
7368GO:0016021IEAComponentintegral to membrane
7368GO:0016758IEAFunctiontransferase activity, transferring hexosyl groups
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
7368CGT_HUMANQ16880IPR002213UDP_glucos_transUDP-glucuronosyl/UDP-glucosyltransferase

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