Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:7378
Official Symbol:UPP1
Other Aliases:UDRPASE|UP|UPASE|UPP
See related:HGNC:12576|MIM:191730|HPRD:08932
Chromosome:7
Location:7p12.3
Gene Description:uridine phosphorylase 1
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0257
ORGANISM:human
Entrez Gene ID:7378
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:15816859
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Prefrontal Cortex
Drug Effects:Upregulated
Fold Change:0.75
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
22271CBCerebellum3.15844500064854.41930544376373
22271CTXCerebral cortex4.676541805267334.02718031406403
22271HIPHippocampal region5.285538077354436.09197545051575
22271HPFHippocampal formation4.921495437622075.16714763641357
22271HYHypothalamus0.51055242959410.417984955944121
22271LSXLateral septal complex0.4345447495579720.514672160148621
22271MBMidbrain1.998629897832872.30955410003662
22271MYMedulla5.668617069721227.71844148635864
22271OLFOlfactory bulb9.242662191390999.06630837917328
22271PPons3.628714218735693.47895911335945
22271PALPallidum0.6704549081623550.519402135163546
22271RHPRetrohippocampal region4.352775454521183.88034647703171
22271sAMYStriatum-like amygdalar nuclei1.220290854573251.00041075050831
22271STRStriatum0.9701234102249150.846339672803879
22271STRdStriatum dorsal region0.9789867997169490.879316627979279
22271STRvStriatum ventral region0.8290775865316390.585782408714294
22271THThalamus1.691794008016591.68505904078484
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
7378GO:0004850TASFunctionuridine phosphorylase activity
7378GO:0005737IEAComponentcytoplasm
7378GO:0009116IEAProcessnucleoside metabolism
7378GO:0009166IEAProcessnucleotide catabolism
7378GO:0016757IEAFunctiontransferase activity, transferring glycosyl groups
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
NP_003355.17431NP_003371.1vimentinHPRD08932
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
7378UPP1_HUMANQ16831IPR000845PNP_UDPPurine and other phosphorylases, family 1

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