Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:7384
Official Symbol:UQCRC1
Other Aliases:D3S3191
See related:HGNC:12585|MIM:191328|HPRD:01875
Chromosome:3
Location:3p21.3
Gene Description:ubiquinol-cytochrome c reductase core protein I
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0526
ORGANISM:human
Entrez Gene ID:7384
Evidence Type:Mapping from rat
Evidence ID Type:Entrez Gene
Evidence ID:301011
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 2
KARG ID:QTL0153
ORGANISM:human
Entrez Gene ID:7384
Evidence Type:QTL assay
Evidence ID Type:PUBMED
Evidence ID:NA
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
22273CBCerebellum42.666700363159263.7930784225464
22273CTXCerebral cortex100.0100.0
22273HIPHippocampal region97.053596496582100.0
22273HPFHippocampal formation92.8868293762207100.0
22273HYHypothalamus100.0100.0
22273LSXLateral septal complex100.0100.0
22273MBMidbrain66.012018203735471.6478939056396
22273MYMedulla56.28397178649960.8339281082153
22273OLFOlfactory bulb86.58440017700293.511848449707
22273PPons63.32743167877271.284839630127
22273PALPallidum100.0100.0
22273RHPRetrohippocampal region84.739028930664189.9754409790039
22273sAMYStriatum-like amygdalar nuclei100.0100.0
22273STRStriatum100.0100.0
22273STRdStriatum dorsal region100.0100.0
22273STRvStriatum ventral region100.0100.0
22273THThalamus89.425556182861392.0790557861328
KARG Evidence 3
KARG ID:QTL0153
Trait:differences in cocaine responsiveness
Peak:57
Peak Marker:D9MIt2O
Parents:C57BL/6J x DBA/2J intercross
Evidence ID:7932176
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
7384GO:0005739IEAComponentmitochondrion
7384GO:0005746TASComponentmitochondrial electron transport chain
7384GO:0006118TASProcesselectron transport
7384GO:0006119TASProcessoxidative phosphorylation
7384GO:0008121TASFunctionubiquinol-cytochrome-c reductase activity
7384GO:0009060TASProcessaerobic respiration
7384GO:0016020IEAComponentmembrane
7384GO:0016491IEAFunctionoxidoreductase activity
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-7388NP_005995.1ubiquinol-cytochrome c reductase hinge proteinHPRD15629
-54205NP_061820.1cytochrome cHPRD00479
NP_003356.154205-Cytochrome CHPRD01875
NP_003356.157142NP_065393.1reticulon 4 isoform AHPRD07259
NP_003356.157142NP_065393.1reticulon 4 isoform AHPRD01875
NP_003356.257142NP_065393.1reticulon 4 isoform ABIND216863
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
7384UQCR1_HUMANP31930IPR013578M16C_assocPeptidase M16C associated
7384UQCR1_HUMANP31930IPR007863Peptidase_M16_CPeptidase M16, C-terminal
7384UQCR1_HUMANP31930IPR011765Pept_M16_NPeptidase M16, N-terminal

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