Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:7385
Official Symbol:UQCRC2
Other Aliases:-
See related:HGNC:12586|MIM:191329|HPRD:01876
Chromosome:16
Location:16p12
Gene Description:ubiquinol-cytochrome c reductase core protein II
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0180
ORGANISM:human
Entrez Gene ID:7385
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:67003
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 2
KARG ID:EVIM0862
ORGANISM:human
Entrez Gene ID:7385
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:11141048
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Upregulated
Fold Change:1.5 :: 1.4 :: 1.7
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
67003CBCerebellum35.812541961669950.0
67003CTXCerebral cortex50.050.0
67003HIPHippocampal region50.050.0
67003HPFHippocampal formation50.050.0
67003HYHypothalamus50.050.0
67003LSXLateral septal complex50.050.0
67003MBMidbrain50.050.0
67003MYMedulla49.996067047119150.0
67003OLFOlfactory bulb50.050.0
67003PPons47.870693206787150.0
67003PALPallidum50.050.0
67003RHPRetrohippocampal region50.050.0
67003sAMYStriatum-like amygdalar nuclei50.050.0
67003STRStriatum50.050.0
67003STRdStriatum dorsal region50.050.0
67003STRvStriatum ventral region50.050.0
67003THThalamus50.050.0
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
7385GO:0004222IEAFunctionmetalloendopeptidase activity
7385GO:0005739IEAComponentmitochondrion
7385GO:0005746IEAComponentmitochondrial electron transport chain
7385GO:0006118IEAProcesselectron transport
7385GO:0006119TASProcessoxidative phosphorylation
7385GO:0006508IEAProcessproteolysis
7385GO:0008121IEAFunctionubiquinol-cytochrome-c reductase activity
7385GO:0009060TASProcessaerobic respiration
7385GO:0016020IEAComponentmembrane
7385GO:0016491IEAFunctionoxidoreductase activity
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-7388NP_005995.1ubiquinol-cytochrome c reductase hinge proteinHPRD15629
NP_003357.157142NP_065393.1reticulon 4 isoform AHPRD07259
NP_003357.157142NP_065393.1reticulon 4 isoform AHPRD01876
NP_003357.257142NP_065393.1reticulon 4 isoform ABIND216654
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
7385UQCR2_HUMANP22695IPR013578M16C_assocPeptidase M16C associated
7385UQCR2_HUMANP22695IPR007863Peptidase_M16_CPeptidase M16, C-terminal
7385UQCR2_HUMANP22695IPR011765Pept_M16_NPeptidase M16, N-terminal
7385UQCR2_HUMANP22695IPR001431Pept_M16_Zn_BSPeptidase M16, zinc-binding site

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