Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:7389
Official Symbol:UROD
Other Aliases:PCT
See related:HGNC:12591|MIM:176100|HPRD:01441
Chromosome:1
Location:1p34
Gene Description:uroporphyrinogen decarboxylase
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0258
ORGANISM:human
Entrez Gene ID:7389
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:15816859
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Prefrontal Cortex
Drug Effects:Downregulated
Fold Change:-0.51
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
22275CBCerebellum19.528249740600625.1472911834717
22275CTXCerebral cortex30.446146011352525.1685619354248
22275HIPHippocampal region25.521791458129932.7796669006348
22275HPFHippocampal formation22.513137817382825.1314086914062
22275HYHypothalamus15.636630058288613.7156772613525
22275LSXLateral septal complex4.853007316589363.4701681137085
22275MBMidbrain32.577148437534.9004554748535
22275MYMedulla47.506885528564564.8318099975586
22275OLFOlfactory bulb19.046844482421916.9198780059814
22275PPons41.363964080810554.9227523803711
22275PALPallidum16.754182815551816.4057159423828
22275RHPRetrohippocampal region17.386331558227514.6445045471191
22275sAMYStriatum-like amygdalar nuclei4.451992988586434.38374757766724
22275STRStriatum7.058940410614015.79218912124634
22275STRdStriatum dorsal region5.850342750549325.10222053527832
22275STRvStriatum ventral region13.33083629608159.43993949890137
22275THThalamus35.446193695068433.3500633239746
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
7389GO:0004853TASFunctionuroporphyrinogen decarboxylase activity
7389GO:0006783IEAProcessheme biosynthesis
7389GO:0016829IEAFunctionlyase activity
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
7389DCUP_HUMANP06132IPR000257Uro_decarbxylsUroporphyrinogen decarboxylase (URO-D)

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