Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:7416
Official Symbol:VDAC1
Other Aliases:MGC111064|PORIN|PORIN-31-HL
See related:HGNC:12669|MIM:604492|HPRD:05137
Chromosome:5
Location:5q31
Gene Description:voltage-dependent anion channel 1
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0487
ORGANISM:human
Entrez Gene ID:7416
Evidence Type:Mapping from rat
Evidence ID Type:Entrez Gene
Evidence ID:83529
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 2
KARG ID:EVIP0200
ORGANISM:human
Entrez Gene ID:7416
Evidence Type:Proteomics
Evidence ID Type:PUBMED
Evidence ID:15542695
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Whole Brain
Drug Effects:Upregulated
Fold Change:2.10
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
22333CBCerebellum79.9444351196289100.0
22333CTXCerebral cortex100.0100.0
22333HIPHippocampal region100.0100.0
22333HPFHippocampal formation100.0100.0
22333HYHypothalamus100.0100.0
22333LSXLateral septal complex100.0100.0
22333MBMidbrain100.0100.0
22333MYMedulla100.0100.0
22333OLFOlfactory bulb100.0100.0
22333PPons100.0100.0
22333PALPallidum100.0100.0
22333RHPRetrohippocampal region100.0100.0
22333sAMYStriatum-like amygdalar nuclei100.0100.0
22333STRStriatum100.0100.0
22333STRdStriatum dorsal region100.0100.0
22333STRvStriatum ventral region100.0100.0
22333THThalamus100.0100.0
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
7416GO:0005739TASComponentmitochondrion
7416GO:0005741TASComponentmitochondrial outer membrane
7416GO:0006820TASProcessanion transport
7416GO:0008308IEAFunctionvoltage-gated ion-selective channel activity
7416GO:0008632TASProcessapoptotic program
7416GO:0015283TASFunctionapoptogenic cytochrome c release channel activity
7416GO:0015482TASFunctionvoltage-gated anion channel porin activity
7416GO:0016021IEAComponentintegral to membrane
7416GO:0019867IEAComponentouter membrane
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-54205NP_061820.1cytochrome cHPRD00479
-10018NP_619527.1BCL2-like 11 isoform 1HPRD04828
NP_003365.1--PK11195 binding subunitHPRD05137
NP_003365.1--mtHSP70HPRD05137
NP_003365.110018-BCL2 interacting protein BIMHPRD05137
NP_003365.154205-Cytochrome CHPRD05137
NP_003365.19804NP_055580.1translocase of outer mitochondrial membrane 20 homologHPRD03507
NP_003365.19804NP_055580.1translocase of outer mitochondrial membrane 20 homologHPRD05137
NP_003365.1155807NP_057852.2Vpr--
NP_003365.1904054NP_275030.1major outer membrane protein PIBBIND19084
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
7416VDAC1_HUMANP21796IPR001925Porin_EukPorin, eukaryotic type

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