Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:7514
Official Symbol:XPO1
Other Aliases:CRM1|DKFZp686B1823
See related:HGNC:12825|MIM:602559|HPRD:03975
Chromosome:2
Location:2p16
Gene Description:exportin 1 (CRM1 homolog, yeast)
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0307
ORGANISM:human
Entrez Gene ID:7514
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:103573
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
103573CBCerebellum0.9982926249504091.04508769512177
103573CTXCerebral cortex14.040449142456110.2274045944214
103573HIPHippocampal region19.640548706054723.4637088775635
103573HPFHippocampal formation14.405095100402815.920147895813
103573HYHypothalamus25.147926330566419.8412532806396
103573LSXLateral septal complex34.320926666259825.6747913360596
103573MBMidbrain1.999182939529422.44953536987305
103573MYMedulla0.1371150910854340.211570888757706
103573OLFOlfactory bulb15.743083953857412.4902467727661
103573PPons0.4370987713336940.613168954849243
103573PALPallidum27.412557601928721.3467922210693
103573RHPRetrohippocampal region3.100864648818972.93330764770508
103573sAMYStriatum-like amygdalar nuclei40.094566345214827.994010925293
103573STRStriatum13.713933944702110.2058391571045
103573STRdStriatum dorsal region5.112039089202884.50060272216797
103573STRvStriatum ventral region15.28067398071299.86343288421631
103573THThalamus17.405654907226614.668231010437
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
7514GO:0000059IEAProcessprotein import into nucleus, docking
7514GO:0003723IEAFunctionRNA binding
7514GO:0005515IPIFunctionprotein binding
7514GO:0005643IEAComponentnuclear pore
7514GO:0005654TASComponentnucleoplasm
7514GO:0005737TASComponentcytoplasm
7514GO:0006397IEAProcessmRNA processing
7514GO:0006406IEAProcessmRNA export from nucleus
7514GO:0008565IEAFunctionprotein transporter activity
7514GO:0015031IEAProcessprotein transport
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-9972NP_005115.2nucleoporin 153kDaHPRD04899
-10762NP_009103.2nucleoporin 50kDa isoform bHPRD05226
-57576NP_065867.1kinesin family member 17HPRD10388
-51808NP_115553.1hypothetical protein FLJ13193HPRD15122
-23636NP_714941.1nucleoporin 62kDaHPRD05782
NP_003391.1--PKIHPRD03975
NP_003391.1--NXT1HPRD03975
NP_003391.1--HuRHPRD03975
NP_003391.1--pp32HPRD03975
NP_003391.1--KIF17bHPRD03975
NP_003391.1--NMD3HPRD03975
NP_003391.19972-NUP153HPRD03975
NP_003391.123636-NUP62HPRD03975
NP_003391.18678NP_003757.1beclin 1HPRD05087
NP_003391.18678NP_003757.1beclin 1HPRD03975
NP_003391.18841NP_003874.2histone deacetylase 3HPRD03975
NP_003391.18021NP_005076.3nucleoporin 214kDaHPRD03975
NP_003391.18021NP_005076.3nucleoporin 214kDaHPRD00258
NP_003391.110073NP_005692.1RNA, U transporter 1HPRD03975
NP_003391.110073NP_005692.1RNA, U transporter 1HPRD07441
NP_003391.18498NP_015561.1RAN binding protein 3 isoform RANBP3-dHPRD03975
NP_003391.18498NP_015561.1RAN binding protein 3 isoform RANBP3-dHPRD04508
NP_003391.111097NP_031368.1nucleoporin like 2BIND214583
NP_003391.129107NP_037380.1NTF2-like export factor 1HPRD16159
NP_003391.151068NP_057022.2NMD3 homologHPRD13026
NP_003391.157154NP_065162.1Smad ubiquitination regulatory factor 1 isoform 1HPRD03975
NP_003391.157154NP_065162.1Smad ubiquitination regulatory factor 1 isoform 1HPRD06902
NP_003391.156000NP_071335.1nuclear RNA export factor 3HPRD02261
NP_003391.156000NP_071335.1nuclear RNA export factor 3HPRD03975
NP_003391.1407977NP_742086.1tumor necrosis factor (ligand) superfamily, member 12-member 13HPRD03975
NP_003391.1407977NP_742086.1tumor necrosis factor (ligand) superfamily, member 12-member 13HPRD05128
NP_003391.1155807NP_057852.2Vpr--
NP_003391.1155807NP_057852.2Vpr--
NP_003391.1155908NP_057854.1Rev--
NP_003391.1155908NP_057854.1Rev--
NP_003391.1155908NP_057854.1Rev--
NP_003391.1155908NP_057854.1Rev--
NP_003391.1155908NP_057854.1Rev--
NP_003391.1155908NP_057854.1Rev--
NP_003391.1155908NP_057854.1Rev--
NP_003391.1155908NP_057854.1Rev--
NP_003391.1155908NP_057854.1Rev--
NP_003391.1155908NP_057854.1Rev--
NP_003391.1155908NP_057854.1Rev--
NP_003391.1155908NP_057854.1Rev--
NP_003391.1155908NP_057854.1Rev--
NP_003391.1155908NP_057854.1Rev--
NP_003391.1155030NP_579876.2matrix--
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
7514XPO1_HUMANO14980IPR001494Importinb_NImportin-beta, N-terminal
7514XPO1_HUMANO14980IPR013598Xpo1Exportin 1-like

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