Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:7529
Official Symbol:YWHAB
Other Aliases:GW128|HS1|KCIP-1
See related:HGNC:12849|MIM:601289|HPRD:03184
Chromosome:20
Location:20q13.1
Gene Description:tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0867
ORGANISM:human
Entrez Gene ID:7529
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:11141048
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Upregulated
Fold Change:1.4 :: 1.4 :: 1.2 :: 1.3
KARG Evidence 2
KARG ID:EVIP0220
ORGANISM:human
Entrez Gene ID:7529
Evidence Type:Proteomics
Evidence ID Type:PUBMED
Evidence ID:15542695
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Whole Brain
Drug Effects:Downregulated
Fold Change:0.43
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
54401CBCerebellum60.452613830566479.9021835327148
54401CTXCerebral cortex100.0100.0
54401HIPHippocampal region86.4253120422363100.0
54401HPFHippocampal formation100.0100.0
54401HYHypothalamus88.406463623046991.377498626709
54401LSXLateral septal complex73.144763946533270.0977973937988
54401MBMidbrain88.770095825195398.0164260864258
54401MYMedulla97.9268112182617100.0
54401OLFOlfactory bulb100.0100.0
54401PPons98.0830001831055100.0
54401PALPallidum81.664173126220790.2891845703125
54401RHPRetrohippocampal region100.0100.0
54401sAMYStriatum-like amygdalar nuclei93.428684234619188.26416015625
54401STRStriatum84.770324707031280.4347267150879
54401STRdStriatum dorsal region79.048976898193468.9360027313232
54401STRvStriatum ventral region100.093.1154708862305
54401THThalamus94.9488906860352100.0
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
7529GO:0004497IEAFunctionmonooxygenase activity
7529GO:0019904IEAFunctionprotein domain specific binding
7529GO:0048471IDAComponentperinuclear region
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-10420BAB62909.1testicular protein kinase 2HPRD05298
-7538NP_003398.1zinc finger protein 36, C3H type, homologHPRD01835
-10749NP_006603.1kinesin family member 1CHPRD04342
-23136NP_036439.2erythrocyte membrane protein band 4.1-like 3HPRD05622
-132954NP_689614.2phosducin-like 2HPRD15109
NP_003395.1--RemHPRD03184
NP_003395.110749-KIF1CHPRD03184
NP_003395.110420-Testis specific protein kinase 2HPRD03184
NP_003395.17538-ZFP36HPRD03184
NP_003395.123136-Band 4.1 like protein 3HPRD03184
NP_003395.17529NP_003395.1tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptideHPRD03184
NP_003395.19610NP_004283.1ras inhibitor RIN1HPRD05813
NP_003395.19610NP_004283.1ras inhibitor RIN1HPRD03184
NP_003395.110014NP_005465.1histone deacetylase 5 isoform 1HPRD03184
NP_003395.110014NP_005465.1histone deacetylase 5 isoform 1HPRD09246
NP_003395.122877NP_055753.2mondoAHPRD10478
NP_003395.1200186NP_859066.1transducer of regulated cAMP response element-binding protein (CREB) 2BIND181863
NP_003395.1951475NP_751919.1core proteinBIND144521
NP_003395.1155807NP_057852.2Vpr--
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
75291433B_HUMANP31946IPR00030814-3-314-3-3 protein

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