Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:7531
Official Symbol:YWHAE
Other Aliases:14-3-3E|FLJ45465|KCIP-1|MDCR|MDS
See related:HGNC:12851|MIM:605066|HPRD:05457
Chromosome:17
Location:17p13.3
Gene Description:tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIP0205
ORGANISM:human
Entrez Gene ID:7531
Evidence Type:Proteomics
Evidence ID Type:PUBMED
Evidence ID:15542695
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Whole Brain
Drug Effects:Downregulated
Fold Change:0.43
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
7531GO:0019904IEAFunctionprotein domain specific binding
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-8660NP_003740.2insulin receptor substrate 2HPRD02878
-9759NP_006028.1histone deacetylase 4HPRD05610
-10749NP_006603.1kinesin family member 1CHPRD04342
-28954NP_054731.2RAS-like GTP-binding protein REMHPRD15237
-27018NP_055195.1nerve growth factor receptor (TNFRSF16) associated protein 1 isoform bHPRD02291
-25937NP_056287.1WW domain containing transcription regulator 1HPRD09580
-81565NP_110435.1nudE nuclear distribution gene E homolog like 1 (A. nidulans) isoform BHPRD06340
-10914NP_116021.2poly(A) polymerase alphaHPRD10407
NP_006752.1--MEKK1HPRD05457
NP_006752.1--MEKK2HPRD05457
NP_006752.1--RemHPRD05457
NP_006752.18660-IRS2HPRD05457
NP_006752.110749-KIF1CHPRD05457
NP_006752.125937-TAZHPRD05457
NP_006752.127018-NGFR associated protein 1HPRD05457
NP_006752.19759-Histone deacetylase 4HPRD05457
NP_006752.164283-Rho guanine nucleotide exchange factorHPRD15244
NP_006752.181565-Nude like proteinHPRD05457
NP_006752.19181AAL96658.1Homo sapiens guanine nucleotide exchange factor GEF-H1 mRNA, complete cds.HPRD10458
NP_006752.19610NP_004283.1ras inhibitor RIN1HPRD05457
NP_006752.19610NP_004283.1ras inhibitor RIN1HPRD05813
NP_006752.110014NP_005465.1histone deacetylase 5 isoform 1HPRD05457
NP_006752.110014NP_005465.1histone deacetylase 5 isoform 1HPRD09246
NP_006752.19612NP_006303.1nuclear receptor co-repressor 2BIND182702
NP_006752.110746NP_006600.2mitogen-activated protein kinase kinase kinase 2HPRD10068
NP_006752.123118NP_055908.1mitogen-activated protein kinase kinase kinase 7 interacting protein 2HPRD05483
NP_006752.1951475NP_751919.1core proteinBIND144546
NP_006752.1155807NP_057852.2Vpr--
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
75311433E_HUMANP62258IPR00030814-3-314-3-3 protein

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