Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:7532
Official Symbol:YWHAG
Other Aliases:14-3-3GAMMA
See related:HGNC:12852|MIM:605356|HPRD:05639
Chromosome:7
Location:7q11.23
Gene Description:tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0426
ORGANISM:human
Entrez Gene ID:7532
Evidence Type:Mapping from rat
Evidence ID Type:Entrez Gene
Evidence ID:56010
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 2
KARG ID:EVIP0207
ORGANISM:human
Entrez Gene ID:7532
Evidence Type:Proteomics
Evidence ID Type:PUBMED
Evidence ID:15542695
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Whole Brain
Drug Effects:Downregulated
Fold Change:0.47
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
22628CBCerebellum61.534402211507283.6652984619141
22628CTXCerebral cortex100.0100.0
22628HIPHippocampal region100.0100.0
22628HPFHippocampal formation100.0100.0
22628HYHypothalamus100.0100.0
22628LSXLateral septal complex95.000592549641990.0659713745117
22628MBMidbrain100.0100.0
22628MYMedulla95.70640818278100.0
22628OLFOlfactory bulb100.0100.0
22628PPons96.8487726847331100.0
22628PALPallidum96.1295115152995100.0
22628RHPRetrohippocampal region100.0100.0
22628sAMYStriatum-like amygdalar nuclei100.0100.0
22628STRStriatum76.905583699544377.0925992329915
22628STRdStriatum dorsal region60.132181803385462.052298227946
22628STRvStriatum ventral region81.7755673726473.9782244364421
22628THThalamus97.519152323405100.0
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
7532GO:0003779ISSFunctionactin binding
7532GO:0005080IPIFunctionprotein kinase C binding
7532GO:0005159IPIFunctioninsulin-like growth factor receptor binding
7532GO:0005737ISSComponentcytoplasm
7532GO:0006469NASProcessnegative regulation of protein kinase activity
7532GO:0007010ISSProcesscytoskeleton organization and biogenesis
7532GO:0007088ISSProcessregulation of mitosis
7532GO:0008426NASFunctionprotein kinase C inhibitor activity
7532GO:0009966NASProcessregulation of signal transduction
7532GO:0019904IEAFunctionprotein domain specific binding
7532GO:0042803NASFunctionprotein homodimerization activity
7532GO:0043066ISSProcessnegative regulation of apoptosis
7532GO:0045664IMPProcessregulation of neuron differentiation
7532GO:0048167IMPProcessregulation of synaptic plasticity
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-27185NP_061132.1disrupted in schizophrenia 1HPRD05553
NP_036611.227185-DISC1HPRD05639
NP_036611.255660AAH27178.1PRPF40A proteinHPRD10995
NP_036611.29181AAL96658.1Homo sapiens guanine nucleotide exchange factor GEF-H1 mRNA, complete cds.HPRD10458
NP_036611.227342BAC87138.1unnamed protein productHPRD11477
NP_036611.27538NP_003398.1zinc finger protein 36, C3H type, homologHPRD01835
NP_036611.27538NP_003398.1zinc finger protein 36, C3H type, homologHPRD05639
NP_036611.29360NP_004783.2peptidyl-prolyl isomerase G (cyclophilin G)HPRD12083
NP_036611.29414NP_004808.2tight junction protein 2 (zona occludens 2) isoform 1HPRD06369
NP_036611.210250NP_005830.2serine/arginine repetitive matrix 1HPRD10441
NP_036611.210746NP_006600.2mitogen-activated protein kinase kinase kinase 2HPRD10068
NP_036611.210749NP_006603.1kinesin family member 1CHPRD04342
NP_036611.210749NP_006603.1kinesin family member 1CHPRD05639
NP_036611.211214NP_006729.4A-kinase anchor protein 13 isoform 1HPRD05253
NP_036611.223136NP_036439.2erythrocyte membrane protein band 4.1-like 3HPRD05622
NP_036611.223136NP_036439.2erythrocyte membrane protein band 4.1-like 3HPRD05639
NP_036611.223450NP_036558.3splicing factor 3b, subunit 3HPRD12027
NP_036611.227339NP_055317.1PRP19/PSO4 pre-mRNA processing factor 19 homologHPRD12214
NP_036611.29774NP_055554.1BCL2-associated transcription factor 1HPRD16544
NP_036611.29855NP_055623.1FERM, RhoGEF and pleckstrin domain protein 2HPRD16885
NP_036611.222841NP_055719.1RAB11 family interacting protein 2 (class I)HPRD10548
NP_036611.223077NP_055872.1MYC binding protein 2HPRD10104
NP_036611.223085NP_055879.1RAB6-interacting protein 2 isoform alphaHPRD06181
NP_036611.223095NP_055889.1kinesin family member 1BHPRD05818
NP_036611.223164NP_055949.2myosin phosphatase-Rho interacting protein isoform 1HPRD17591
NP_036611.223216NP_055988.2TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1HPRD18161
NP_036611.223294NP_056060.1ankyrin repeat and sterile alpha motif domain containing 1HPRD10610
NP_036611.223367NP_056130.2la related protein isoform 1HPRD11225
NP_036611.223034NP_056404.1sterile alpha motif domain containing 4HPRD10209
NP_036611.251631NP_057103.1LUC7-like 2HPRD17456
NP_036611.251747NP_057508.2cisplatin resistance-associated overexpressed proteinHPRD16759
NP_036611.255095NP_060498.2sterile alpha motif domain containing 4BHPRD10960
NP_036611.254471NP_061881.2hypothetical protein LOC54471HPRD13371
NP_036611.249854NP_065778.2zinc finger protein 295HPRD10328
NP_036611.257530NP_065821.1cingulinHPRD10827
NP_036611.279801NP_079021.2SHC SH2-domain binding protein 1HPRD11557
NP_036611.280851NP_085148.1SH3-binding domain protein 5-likeHPRD13887
NP_036611.285377NP_203744.1molecule interacting with Rab13HPRD11363
NP_036611.285440NP_212132.2dedicator of cytokinesis 7HPRD16833
NP_036611.29493NP_612565.1kinesin family member 23 isoform 1HPRD05455
NP_036611.2122786NP_689543.1FERM domain containing 6HPRD12646
NP_036611.2117583NP_689739.3amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 19 isoform bHPRD09795
NP_036611.255103NP_689876.2Ral GEF with PH domain and SH3 binding motif 2 isoform 2HPRD15206
NP_036611.29462NP_733793.1RAS protein activator like 2 isoform 2HPRD05845
NP_036611.2147700NP_803136.1kinesin light chain 2-like isoform aHPRD03212
NP_036611.2200186NP_859066.1transducer of regulated cAMP response element-binding protein (CREB) 2HPRD12347
NP_036611.251599NP_991403.1LISCH protein isoform 2HPRD17283
NP_036611.2155807NP_057852.2Vpr--
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
75321433G_HUMANP61981IPR00030814-3-314-3-3 protein

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