Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:7533
Official Symbol:YWHAH
Other Aliases:YWHA1
See related:HGNC:12853|MIM:113508|HPRD:00215
Chromosome:22
Location:22q12.3
Gene Description:tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0155
ORGANISM:human
Entrez Gene ID:7533
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12629581
Addiction Drug:COCAINE
Addiction Drug Detail:COCAINE ABUSE
Addiction Brain Area:Dorsolateral Prefrontal Cortex
Drug Effects:Upregulated/Downregulated
Fold Change:3.76 :: 3.99 :: 7.10 :: 2.53 :: -2.93 :: -4.90 :: 0.37
KARG Evidence 2
KARG ID:EVIM0328
ORGANISM:human
Entrez Gene ID:7533
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:15816859
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Nucleus Accumbens
Drug Effects:Downregulated
Fold Change:-0.56
KARG Evidence 3
KARG ID:EVIP0208
ORGANISM:human
Entrez Gene ID:7533
Evidence Type:Proteomics
Evidence ID Type:PUBMED
Evidence ID:15542695
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Whole Brain
Drug Effects:Downregulated
Fold Change:0.30
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
22629CBCerebellum37.1772975921631100.0
22629CTXCerebral cortex100.0100.0
22629HIPHippocampal region100.0100.0
22629HPFHippocampal formation100.0100.0
22629HYHypothalamus100.0100.0
22629LSXLateral septal complex88.448829650878996.2230072021484
22629MBMidbrain100.0100.0
22629MYMedulla92.8409156799316100.0
22629OLFOlfactory bulb100.0100.0
22629PPons95.5144157409668100.0
22629PALPallidum99.5409317016602100.0
22629RHPRetrohippocampal region100.0100.0
22629sAMYStriatum-like amygdalar nuclei100.0100.0
22629STRStriatum66.303396224975679.7949714660645
22629STRdStriatum dorsal region47.688344955444356.2133293151855
22629STRvStriatum ventral region93.41973495483497.4761009216309
22629THThalamus100.0100.0
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
7533GO:0003779ISSFunctionactin binding
7533GO:0005159ISSFunctioninsulin-like growth factor receptor binding
7533GO:0005737ISSComponentcytoplasm
7533GO:0006469ISSProcessnegative regulation of protein kinase activity
7533GO:0006713IDAProcessglucocorticoid catabolism
7533GO:0006886ISSProcessintracellular protein transport
7533GO:0007010ISSProcesscytoskeleton organization and biogenesis
7533GO:0007088ISSProcessregulation of mitosis
7533GO:0008426ISSFunctionprotein kinase C inhibitor activity
7533GO:0009966ISSProcessregulation of signal transduction
7533GO:0016563IDAFunctiontranscriptional activator activity
7533GO:0019904ISSFunctionprotein domain specific binding
7533GO:0035259IPIFunctionglucocorticoid receptor binding
7533GO:0042921IDAProcessglucocorticoid receptor signaling pathway
7533GO:0043066ISSProcessnegative regulation of apoptosis
7533GO:0045664ISSProcessregulation of neuron differentiation
7533GO:0045941IDAProcesspositive regulation of transcription
7533GO:0048167ISSProcessregulation of synaptic plasticity
7533GO:0050774ISSProcessnegative regulation of dendrite morphogenesis
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-8648NP_003734.3nuclear receptor coactivator 1 isoform 1HPRD04070
-8202NP_006525.1nuclear receptor coactivator 3HPRD03570
-10499NP_006531.1nuclear receptor coactivator 2HPRD09066
-28954NP_054731.2RAS-like GTP-binding protein REMHPRD15237
-9699NP_055492.2regulating synaptic membrane exocytosis 2HPRD09436
NP_003396.110499-TIF2HPRD00215
NP_003396.18202-NCOA3HPRD00215
NP_003396.18648-SRC1HPRD00215
NP_003396.164283-Rho guanine nucleotide exchange factorHPRD15244
NP_003396.19699-Regulating synaptic membrane exocytosis 2HPRD00215
NP_003396.19063--BIND183825
NP_003396.17538NP_003398.1zinc finger protein 36, C3H type, homologHPRD01835
NP_003396.17538NP_003398.1zinc finger protein 36, C3H type, homologHPRD00215
NP_003396.18204NP_003480.1receptor interacting protein 140HPRD03927
NP_003396.18204NP_003480.1receptor interacting protein 140HPRD00215
NP_003396.123136NP_036439.2erythrocyte membrane protein band 4.1-like 3HPRD05622
NP_003396.123136NP_036439.2erythrocyte membrane protein band 4.1-like 3HPRD00215
NP_003396.122895NP_055769.2rabphilin 3A homologHPRD15273
NP_003396.1147700NP_803136.1kinesin light chain 2-like isoform aHPRD03212
NP_003396.1147700NP_803136.1kinesin light chain 2-like isoform aHPRD00215
NP_003396.1155807NP_057852.2Vpr--
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
75331433F_HUMANQ04917IPR00030814-3-314-3-3 protein

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