Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:760
Official Symbol:CA2
Other Aliases:CA II|CA-II|CAII|Car2
See related:HGNC:1373|MIM:259730|HPRD:02023
Chromosome:8
Location:8q22
Gene Description:carbonic anhydrase II
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0472
ORGANISM:human
Entrez Gene ID:760
Evidence Type:Mapping from rat
Evidence ID Type:Entrez Gene
Evidence ID:54231
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 2
KARG ID:EVIM0323
ORGANISM:human
Entrez Gene ID:760
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:15816859
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Nucleus Accumbens
Drug Effects:Downregulated
Fold Change:-0.69
KARG Evidence 3
KARG ID:EVIM0346
ORGANISM:human
Entrez Gene ID:760
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:15816859
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Nucleus Accumbens
Drug Effects:Downregulated
Fold Change:-0.67
KARG Evidence 4
KARG ID:EVIM0831
ORGANISM:human
Entrez Gene ID:760
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:11141048
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Downregulated
Fold Change:-1.2 :: -1.3 :: -1.6 :: -1.6
KARG Evidence 5
KARG ID:EVIP0221
ORGANISM:human
Entrez Gene ID:760
Evidence Type:Proteomics
Evidence ID Type:PUBMED
Evidence ID:15542695
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Whole Brain
Drug Effects:Downregulated
Fold Change:0.46
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
12349CBCerebellum95.0675964355469100.0
12349CTXCerebral cortex70.422660827636773.3988513946533
12349HIPHippocampal region76.4050712585449100.0
12349HPFHippocampal formation77.818225860595795.5744743347168
12349HYHypothalamus100.0100.0
12349LSXLateral septal complex90.442955017089895.8906402587891
12349MBMidbrain100.0100.0
12349MYMedulla100.0100.0
12349OLFOlfactory bulb73.329170227050885.4612998962402
12349PPons100.0100.0
12349PALPallidum100.0100.0
12349RHPRetrohippocampal region80.151229858398482.0742835998535
12349sAMYStriatum-like amygdalar nuclei96.096271514892694.5310592651367
12349STRStriatum94.435260772705197.8347816467285
12349STRdStriatum dorsal region98.9591369628906100.0
12349STRvStriatum ventral region64.983890533447359.1087417602539
12349THThalamus100.0100.0
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
760GO:0004089TASFunctioncarbonate dehydratase activity
760GO:0005737NRComponentcytoplasm
760GO:0006730IEAProcessone-carbon compound metabolism
760GO:0008270IEAFunctionzinc ion binding
760GO:0016829IEAFunctionlyase activity
760GO:0046872IEAFunctionmetal ion binding
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-3329NP_002147.2chaperoninHPRD00318
-6548NP_003038.2solute carrier family 9, isoform A1HPRD00123
-8655NP_003737.1dynein light chain 1HPRD03334
-9498NP_004849.1solute carrier family 4, sodium bicarbonate cotransporter, member 8HPRD05430
-6508NP_005061.1solute carrier family 4, anion exchanger, member 3 isoform 1HPRD00109
NP_000058.1--AE2HPRD02023
NP_000058.1--NonOHPRD02023
NP_000058.13329-Heat shock 60 KD protein 1HPRD02023
NP_000058.16508-Solute carrier family 4 (anion exchange), member 3HPRD02023
NP_000058.16548-Solute carrier family 9, isoform A1HPRD02023
NP_000058.19498-Solute carrier family 4, member 8HPRD02023
NP_000058.18655-DLC1HPRD02023
NP_000058.16521NP_000333.1solute carrier family 4, anion exchanger, member 1HPRD02023
NP_000058.16521NP_000333.1solute carrier family 4, anion exchanger, member 1HPRD00175
NP_000058.18671NP_003750.1solute carrier family 4, sodium bicarbonate cotransporter, member 4HPRD02023
NP_000058.18671NP_003750.1solute carrier family 4, sodium bicarbonate cotransporter, member 4HPRD04516
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
760CAH2_HUMANP00918IPR001148Euk_COanhdCarbonic anhydrase, eukaryotic

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