Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:7704
Official Symbol:ZBTB16
Other Aliases:PLZF|ZNF145
See related:HGNC:12930|MIM:176797|HPRD:11762
Chromosome:11
Location:11q23.1
Gene Description:zinc finger and BTB domain containing 16
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0304
ORGANISM:human
Entrez Gene ID:7704
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:235320
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
235320CBCerebellum1.512829303741461.84281671047211
235320CTXCerebral cortex50.046.1326637268066
235320HIPHippocampal region50.050.0
235320HPFHippocampal formation50.050.0
235320HYHypothalamus1.364923954010011.09091734886169
235320LSXLateral septal complex10.46945953369148.40440273284912
235320MBMidbrain6.875408649444586.46813631057739
235320MYMedulla7.498709201812747.99233722686768
235320OLFOlfactory bulb16.711772918701214.2840127944946
235320PPons2.780088424682622.80259251594543
235320PALPallidum5.318393230438235.2833080291748
235320RHPRetrohippocampal region50.050.0
235320sAMYStriatum-like amygdalar nuclei3.657716274261472.8027229309082
235320STRStriatum4.805094242095953.87509942054749
235320STRdStriatum dorsal region3.855711936950683.22254538536072
235320STRvStriatum ventral region5.906950950622564.39560890197754
235320THThalamus5.071215629577645.55518913269043
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
7704GO:0001823ISSProcessmesonephros development
7704GO:0003676IEAFunctionnucleic acid binding
7704GO:0003677NASFunctionDNA binding
7704GO:0005515IEAFunctionprotein binding
7704GO:0005634IDAComponentnucleus
7704GO:0005634IEAComponentnucleus
7704GO:0006350IEAProcesstranscription
7704GO:0006915NASProcessapoptosis
7704GO:0007417ISSProcesscentral nervous system development
7704GO:0008270IEAFunctionzinc ion binding
7704GO:0016566IDAFunctionspecific transcriptional repressor activity
7704GO:0016607IDAComponentnuclear speck
7704GO:0017053IDAComponenttranscriptional repressor complex
7704GO:0030099TASProcessmyeloid cell differentiation
7704GO:0042803IDAFunctionprotein homodimerization activity
7704GO:0045638ISSProcessnegative regulation of myeloid cell differentiation
7704GO:0045892IDAProcessnegative regulation of transcription, DNA-dependent
7704GO:0046872IEAFunctionmetal ion binding
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
NP_005997.2--Histone deacetylase 7AHPRD11762
NP_005997.29611-Nuclear receptor corepressor 1HPRD11762
NP_005997.223309-SIN3BHPRD11762
NP_005997.225942-SIN3AHPRD11762
NP_005997.229924-Epsin 1HPRD11762
NP_005997.210014-Histone deacetylase 5HPRD11762
NP_005997.29759-Histone deacetylase 4HPRD11762
NP_005997.210013-Histone deacetylase 6HPRD11762
NP_005997.27704NP_005997.2promyelocytic leukemia zinc finger proteinHPRD11762
NP_005997.29612NP_006303.1nuclear receptor co-repressor 2HPRD11762
NP_005997.29612NP_006303.1nuclear receptor co-repressor 2BIND128174
NP_005997.210628NP_006463.2thioredoxin interacting proteinHPRD11762
NP_005997.227033NP_055198.1testis zinc finger proteinHPRD12055
NP_005997.227033NP_055198.1testis zinc finger proteinHPRD11762
NP_005997.225942NP_056292.1transcriptional co-repressor Sin3ABIND128172
NP_005997.29734NP_848512.1histone deacetylase 9 isoform 5HPRD11762
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
7704ZBT16_HUMANQ05516IPR000210BTBBTB
7704ZBT16_HUMANQ05516IPR013069BTB_POZBTB/POZ
7704ZBT16_HUMANQ05516IPR007087Znf_C2H2Zinc finger, C2H2-type
7704ZBT16_HUMANQ05516IPR007086Znf_C2H2_subZinc finger, C2H2-subtype

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