Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:773
Official Symbol:CACNA1A
Other Aliases:APCA|CACNL1A4|CAV2.1|EA2|FHM|HPCA|MHP|MHP1|SCA6
See related:HGNC:1388|MIM:601011|HPRD:03004
Chromosome:19
Location:19p13.2-p13.1
Gene Description:calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0107
ORGANISM:human
Entrez Gene ID:773
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:12286
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
12286CBCerebellum0.00.0
12286CTXCerebral cortex0.00.0
12286HIPHippocampal region0.00.0
12286HPFHippocampal formation0.00.0
12286HYHypothalamus0.00.0
12286LSXLateral septal complex0.00.0
12286MBMidbrain0.00.0
12286MYMedulla0.00.0
12286OLFOlfactory bulb0.00.0
12286PPons0.00.0
12286PALPallidum0.00.0
12286RHPRetrohippocampal region0.00.0
12286sAMYStriatum-like amygdalar nuclei0.00.0
12286STRStriatum0.00.0
12286STRdStriatum dorsal region0.00.0
12286STRvStriatum ventral region0.00.0
12286THThalamus0.00.0
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
773GO:0005245IDAFunctionvoltage-gated calcium channel activity
773GO:0005245ISSFunctionvoltage-gated calcium channel activity
773GO:0005261IEAFunctioncation channel activity
773GO:0005509IEAFunctioncalcium ion binding
773GO:0005891IEAComponentvoltage-gated calcium channel complex
773GO:0006812IEAProcesscation transport
773GO:0006816IEAProcesscalcium ion transport
773GO:0007204IDAProcesselevation of cytosolic calcium ion concentration
773GO:0007204ISSProcesselevation of cytosolic calcium ion concentration
773GO:0007268TASProcesssynaptic transmission
773GO:0007399TASProcessnervous system development
773GO:0016020IEAComponentmembrane
773GO:0016021ISSComponentintegral to membrane
773GO:0016021NASComponentintegral to membrane
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-785NP_000717.1calcium channel, voltage-dependent, beta 4 subunitHPRD09057
-2782NP_002065.1guanine nucleotide-binding protein, beta-1 subunitBIND300919
-6857NP_005630.1synaptotagmin IHPRD01710
-23446NP_536856.2CDW92 antigen isoform 2HPRD16197
NP_075461.16857-Synaptotagmin 1HPRD03004
NP_075461.1785-Calcium channel voltage dependent beta 4 subunitHPRD03004
NP_075461.123446-CDW92 antigenHPRD03004
NP_075461.19478AAH30201.1CABP1 proteinHPRD12025
NP_075461.19478AAH30201.1CABP1 proteinHPRD03004
NP_075461.1782NP_000714.3calcium channel, voltage-dependent, beta 1 subunit isoform 1HPRD11743
NP_075461.1782NP_000714.3calcium channel, voltage-dependent, beta 1 subunit isoform 1HPRD03004
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
773IPR001682Ca/Na_poreCa2+/Na+ channel, pore region
773IPR002111Cat_channel_TrpLCation (not K+) channel, TM region
773IPR002077Ca_channel_alphaCa2+ channel, alpha subunit
773IPR005821Ion_transIon transport
773IPR013621Ion_trans_NIon transport N-terminal
773IPR003091K_channelVoltage-dependent potassium channel
773IPR005820M+channel_nlgCation channel, non-ligand gated
773IPR005447NVDCCAlpha1N-type voltage-dependent calcium channel alpha 1 subunit
773IPR003915PKD_2Polycystic kidney disease type 2 protein
773IPR005448PQVDCCAlpha1P/Q-type voltage-dependent calcium channel alpha 1 subunit

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