Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:776
Official Symbol:CACNA1D
Other Aliases:CACH3|CACN4|CACNL1A2|CCHL1A2
See related:HGNC:1391|MIM:114206|HPRD:00247
Chromosome:3
Location:3p14.3
Gene Description:calcium channel, voltage-dependent, L type, alpha 1D subunit
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0408
ORGANISM:human
Entrez Gene ID:776
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12065639
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Downregulated
Fold Change:-1.4 :: -1.4 :: -1.1 :: -1.4 :: -1.2 :: -1.4
KARG Evidence 2
KARG ID:EVIM0476
ORGANISM:human
Entrez Gene ID:776
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12065639
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Motor Cortex
Drug Effects:Downregulated
Fold Change:1 :: -1 :: -1.3 :: -1.9 :: -1.4
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
12289CBCerebellum52.372028350830148.352668762207
12289CTXCerebral cortex100.0100.0
12289HIPHippocampal region94.1271667480469100.0
12289HPFHippocampal formation91.9632339477539100.0
12289HYHypothalamus81.274116516113364.2373504638672
12289LSXLateral septal complex100.075.447998046875
12289MBMidbrain61.460597991943450.3186645507812
12289MYMedulla57.101947784423852.3685684204102
12289OLFOlfactory bulb100.0100.0
12289PPons39.53021621704137.242790222168
12289PALPallidum71.030265808105559.4564247131348
12289RHPRetrohippocampal region88.574409484863372.1854934692383
12289sAMYStriatum-like amygdalar nuclei100.081.0151596069336
12289STRStriatum88.470664978027363.175163269043
12289STRdStriatum dorsal region75.486831665039151.9847679138184
12289STRvStriatum ventral region100.081.8037872314453
12289THThalamus84.815101623535270.2735366821289
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
776GO:0005509IEAFunctioncalcium ion binding
776GO:0005891TASComponentvoltage-gated calcium channel complex
776GO:0006812IEAProcesscation transport
776GO:0006816IEAProcesscalcium ion transport
776GO:0015270TASFunctiondihydropyridine-sensitive calcium channel activity
776GO:0016020IEAComponentmembrane
776GO:0016021IEAComponentintegral to membrane
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-6804NP_004594.1syntaxin 1A (brain)HPRD01721
-2263NP_075261.1fibroblast growth factor receptor 2 isoform 5 precursorHPRD01492
NP_000711.16804-Syntaxin 1AHPRD00247
NP_000711.12263-Fibroblast growth factor receptor 2HPRD00247
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
776IPR001682Ca/Na_poreCa2+/Na+ channel, pore region
776IPR002111Cat_channel_TrpLCation (not K+) channel, TM region
776IPR002077Ca_channel_alphaCa2+ channel, alpha subunit
776IPR005821Ion_transIon transport
776IPR013621Ion_trans_NIon transport N-terminal
776IPR003091K_channelVoltage-dependent potassium channel
776IPR005446LVDCCAlpha1L-type voltage-dependent calcium channel alpha 1 subunit
776IPR005451LVDCCAlpha1CL-type voltage-dependent calcium channel alpha 1C subunit
776IPR005452LVDCCAlpha1DL-type voltage-dependent calcium channel alpha 1D subunit
776IPR005820M+channel_nlgCation channel, non-ligand gated

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