Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:780
Official Symbol:DDR1
Other Aliases:CAK|CD167|DDR|EDDR1|MCK10|NEP|NTRK4|PTK3|PTK3A|RTK6|TRKE
See related:HGNC:2730|MIM:600408|HPRD:02678
Chromosome:6
Location:6p21.3
Gene Description:discoidin domain receptor family, member 1
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0884
ORGANISM:human
Entrez Gene ID:780
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:11141048
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Downregulated
Fold Change:-1.5 :: -2
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
12305CBCerebellum28.995407104492232.9875860214233
12305CTXCerebral cortex22.878953933715817.284405708313
12305HIPHippocampal region19.079750061035219.7778902053833
12305HPFHippocampal formation18.537295341491717.0815057754517
12305HYHypothalamus32.185421943664624.9077272415161
12305LSXLateral septal complex28.423086166381826.7307615280151
12305MBMidbrain32.49064731597928.2111883163452
12305MYMedulla56.024164199829154.3768272399902
12305OLFOlfactory bulb36.729759216308628.6567964553833
12305PPons43.510087966918937.7142295837402
12305PALPallidum32.139768600463926.7884426116943
12305RHPRetrohippocampal region17.202081680297913.1777334213257
12305sAMYStriatum-like amygdalar nuclei18.108994007110613.8778200149536
12305STRStriatum23.938727378845219.4496717453003
12305STRdStriatum dorsal region24.637604713439920.5324211120605
12305STRvStriatum ventral region21.748150825500514.7902598381042
12305THThalamus39.647917747497634.2338724136353
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
780GO:0000166IEAFunctionnucleotide binding
780GO:0004713IEAFunctionprotein-tyrosine kinase activity
780GO:0004714TASFunctiontransmembrane receptor protein tyrosine kinase activity
780GO:0004872IEAFunctionreceptor activity
780GO:0005524IEAFunctionATP binding
780GO:0005887TASComponentintegral to plasma membrane
780GO:0006468IEAProcessprotein amino acid phosphorylation
780GO:0007155TASProcesscell adhesion
780GO:0007169IEAProcesstransmembrane receptor protein tyrosine kinase signaling pathway
780GO:0016020IEAComponentmembrane
780GO:0016740IEAFunctiontransferase activity
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-1281NP_000081.1procollagen, type III, alpha 1HPRD00365
-1290NP_000384.1alpha 2 type V collagen preproproteinHPRD00366
-1280NP_001835.2alpha 1 type II collagen isoform 1HPRD00361
-5335NP_002651.2phospholipase C gamma 1 isoform aHPRD01398
-10818NP_006645.2fibroblast growth factor receptor substrate 2HPRD06372
-1301NP_542196.1alpha 1 type XI collagen isoform B preproproteinHPRD00375
-6464NP_892113.1SHC (Src homology 2 domain containing) transforming protein 1HPRD02780
NP_054699.16464NP_003020.2SHC (Src homology 2 domain containing) transforming protein 1 isoform p52ShcBIND57944
NP_054699.1780NP_054699.1discoidin receptor tyrosine kinase isoform aBIND57945
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
780IPR013543CaMKII_ADCalcium/calmodulin dependent protein kinase II, association-domain
780IPR000421FA58_CCoagulation factor 5/8 type, C-terminal
780IPR003072NOR1_rcptOrphan nuclear receptor, NOR1 type
780IPR000719Prot_kinaseProtein kinase
780IPR000694PRO_richProline-rich region
780IPR002011RecepttyrkinsIIReceptor tyrosine kinase, class II
780IPR001245Tyr_pkinaseTyrosine protein kinase
780IPR008266Tyr_pkinase_ASTyrosine protein kinase, active site
780IPR013695WAKWall-associated kinase
780DDR1_HUMANQ08345IPR013543CaMKII_ADCalcium/calmodulin dependent protein kinase II, association-domain
780DDR1_HUMANQ08345IPR000421FA58_CCoagulation factor 5/8 type, C-terminal
780DDR1_HUMANQ08345IPR003072NOR1_rcptOrphan nuclear receptor, NOR1 type
780DDR1_HUMANQ08345IPR000719Prot_kinaseProtein kinase
780DDR1_HUMANQ08345IPR000694PRO_richProline-rich region
780DDR1_HUMANQ08345IPR002011RecepttyrkinsIIReceptor tyrosine kinase, class II
780DDR1_HUMANQ08345IPR001245Tyr_pkinaseTyrosine protein kinase
780DDR1_HUMANQ08345IPR008266Tyr_pkinase_ASTyrosine protein kinase, active site
780DDR1_HUMANQ08345IPR013695WAKWall-associated kinase

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