Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:7846
Official Symbol:TUBA3
Other Aliases:B-ALPHA-1|FLJ25113
See related:MIM:602529|HPRD:03959
Chromosome:12
Location:12q12-12q14.3
Gene Description:tubulin, alpha 3
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0192
ORGANISM:human
Entrez Gene ID:7846
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:22142
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 2
KARG ID:EVIC0379
ORGANISM:human
Entrez Gene ID:7846
Evidence Type:Mapping from rat
Evidence ID Type:Entrez Gene
Evidence ID:64158
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 3
KARG ID:EVIP0214
ORGANISM:human
Entrez Gene ID:7846
Evidence Type:Proteomics
Evidence ID Type:PUBMED
Evidence ID:15542695
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Whole Brain
Drug Effects:Downregulated
Fold Change:0.28
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
22144CBCerebellum76.2903213500977100.0
22144CTXCerebral cortex100.0100.0
22144HIPHippocampal region100.0100.0
22144HPFHippocampal formation100.0100.0
22144HYHypothalamus100.0100.0
22144LSXLateral septal complex100.0100.0
22144MBMidbrain100.0100.0
22144MYMedulla100.0100.0
22144OLFOlfactory bulb100.0100.0
22144PPons100.0100.0
22144PALPallidum100.0100.0
22144RHPRetrohippocampal region100.0100.0
22144sAMYStriatum-like amygdalar nuclei100.0100.0
22144STRStriatum100.0100.0
22144STRdStriatum dorsal region100.0100.0
22144STRvStriatum ventral region100.0100.0
22144THThalamus100.0100.0
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
7846GO:0000166IEAFunctionnucleotide binding
7846GO:0003924IEAFunctionGTPase activity
7846GO:0005198IEAFunctionstructural molecule activity
7846GO:0005525IEAFunctionGTP binding
7846GO:0005874IEAComponentmicrotubule
7846GO:0007018IEAProcessmicrotubule-based movement
7846GO:0043234IEAComponentprotein complex
7846GO:0051258IEAProcessprotein polymerization
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-9672NP_055469.1syndecan 3HPRD01719
-83988NP_114430.1neurocalcin deltaHPRD09466
NP_006000.29672-Syndecan 3HPRD03959
NP_006000.283988-Neurocalcin deltaHPRD03959
NP_006000.2155871NP_057853.1Tat--
NP_006000.2155908NP_057854.1Rev--
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
7846TBA3_HUMANQ71U36IPR002452Alpha_tubulinAlpha tubulin
7846TBA3_HUMANQ71U36IPR002453Beta_tubulinBeta tubulin
7846TBA3_HUMANQ71U36IPR002967Delta_tubulinDelta tubulin
7846TBA3_HUMANQ71U36IPR004057Epsilon_tubulinEpsilon tubulin
7846TBA3_HUMANQ71U36IPR000158FtsZCell division protein FtsZ
7846TBA3_HUMANQ71U36IPR002454Gamma_tubulinGamma tubulin
7846TBA3_HUMANQ71U36IPR000217TubulinTubulin
7846TBA3_HUMANQ71U36IPR003008Tubulin_FtsZTubulin/FtsZ, GTPase
7846TBA3_HUMANQ71U36IPR008280Tub_FtsZ_CTubulin/FtsZ, C-terminal

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