Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:7849
Official Symbol:PAX8
Other Aliases:-
See related:HGNC:8622|MIM:167415|HPRD:01335
Chromosome:2
Location:2q12-q14
Gene Description:paired box gene 8
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0138
ORGANISM:human
Entrez Gene ID:7849
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12629581
Addiction Drug:COCAINE
Addiction Drug Detail:COCAINE ABUSE
Addiction Brain Area:Dorsolateral Prefrontal Cortex
Drug Effects:Upregulated/Downregulated
Fold Change:-0.65 :: -0.65 :: -0.15 :: 0.47 :: 0.70 :: 1.27 :: 1.45
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
18510CBCerebellum1.898231863975521.7479236125946
18510CTXCerebral cortex0.5410680174827580.341509610414505
18510HIPHippocampal region0.2727351188659670.281939446926117
18510HPFHippocampal formation0.2902677655220030.260337740182877
18510HYHypothalamus0.09536325186491010.0754997059702873
18510LSXLateral septal complex0.03486307337880130.0
18510MBMidbrain0.3711811602115630.238757699728012
18510MYMedulla9.131599426269535.84002637863159
18510OLFOlfactory bulb1.893679857254031.13053488731384
18510PPons0.7486571669578550.437470436096191
18510PALPallidum0.1455174833536150.0904300659894943
18510RHPRetrohippocampal region0.3171458244323730.221475541591644
18510sAMYStriatum-like amygdalar nuclei0.2030727118253710.408571988344193
18510STRStriatum0.2418022453784940.395844429731369
18510STRdStriatum dorsal region0.2321790307760240.496332585811615
18510STRvStriatum ventral region0.4159283638000490.313317775726318
18510THThalamus0.1501235812902450.127418607473373
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
7849GO:0003700TASFunctiontranscription factor activity
7849GO:0004550IEAFunctionnucleoside diphosphate kinase activity
7849GO:0005524IEAFunctionATP binding
7849GO:0005634NASComponentnucleus
7849GO:0006183IEAProcessGTP biosynthesis
7849GO:0006228IEAProcessUTP biosynthesis
7849GO:0006241IEAProcessCTP biosynthesis
7849GO:0006350IEAProcesstranscription
7849GO:0006355IEAProcessregulation of transcription, DNA-dependent
7849GO:0009653TASProcessmorphogenesis
7849GO:0030154IEAProcesscell differentiation
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
7849IPR003071Nuc_orp_HMR_rcptOrphan nuclear receptor, HMR type
7849IPR001523Paired_box_NPaired box protein, N-terminal
7849IPR000694PRO_richProline-rich region
7849PAX8_HUMANQ06710IPR001523Paired_box_NPaired box protein, N-terminal

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