Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:7852
Official Symbol:CXCR4
Other Aliases:CD184|D2S201E|FB22|HM89|HSY3RR|LAP3|LCR1|LESTR|NPY3R|NPYR|NPYRL|NPYY3R|WHIM
See related:HGNC:2561|MIM:162643|HPRD:01217
Chromosome:2
Location:2q21
Gene Description:chemokine (C-X-C motif) receptor 4
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0139
ORGANISM:human
Entrez Gene ID:7852
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:12767
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 2
KARG ID:EVIL0272
ORGANISM:human
Entrez Gene ID:7852
Evidence Type:LT Reports
Evidence ID Type:PUBMED
Evidence ID:12500113
Addiction Drug:ALCOHOL
Addiction Drug Detail:Alcohol down-regulate beta-chemokine productions expression
Addiction Brain Area:Human blood monocyte-derived macrophages
Drug Effects:
Fold Change:
KARG Evidence 3
KARG ID:EVIL0274
ORGANISM:human
Entrez Gene ID:7852
Evidence Type:LT Reports
Evidence ID Type:PUBMED
Evidence ID:12726730
Addiction Drug:OPIOINS
Addiction Drug Detail:Morphine enhances CXCR4 and CCR5 expression and subsequently increases both X4 and R5 HIV-1 infection
Addiction Brain Area:CD3(+) lymphoblasts and CD14(+) monocytes
Drug Effects:
Fold Change:
KARG Evidence 4
KARG ID:EVIL0277
ORGANISM:human
Entrez Gene ID:7852
Evidence Type:LT Reports
Evidence ID Type:PUBMED
Evidence ID:14741421
Addiction Drug:
Addiction Drug Detail:Substance abuse manifest decreased CXCR4 expression
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
7852GO:0001584IEAFunctionrhodopsin-like receptor activity
7852GO:0004872IEAFunctionreceptor activity
7852GO:0007165IEAProcesssignal transduction
7852GO:0007186IEAProcessG-protein coupled receptor protein signaling pathway
7852GO:0016020IEAComponentmembrane
7852GO:0016021IEAComponentintegral to membrane
7852GO:0016493IEAFunctionC-C chemokine receptor activity
7852GO:0016494NASFunctionC-X-C chemokine receptor activity
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-9021NP_003946.2suppressor of cytokine signaling 3HPRD05006
NP_003458.1---BIND144669
NP_003458.19021-SOCS3HPRD01217
NP_003458.1155871NP_057853.1Tat--
NP_003458.1155871NP_057853.1Tat--
NP_003458.1155871NP_057853.1Tat--
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
7852CXCR4_HUMANP61073IPR000248Angtn2_rcptAngiotensin II receptor
7852CXCR4_HUMANP61073IPR000496Brdyknn_rcptBradykinin receptor
7852CXCR4_HUMANP61073IPR005383CC_11_rcptC-C chemokine receptor, type 11
7852CXCR4_HUMANP61073IPR000355Chmkine_rcptChemokine receptor
7852CXCR4_HUMANP61073IPR004070CXC_3_rcptC-X-C chemokine receptor, type 3
7852CXCR4_HUMANP61073IPR001277CXC_4_rcptC-X-C chemokine receptor, type 4
7852CXCR4_HUMANP61073IPR000276GPCR_RhodpsnRhodopsin-like GPCR superfamily
7852CXCR4_HUMANP61073IPR003006Ig_MHCImmunoglobulin/major histocompatibility complex
7852CXCR4_HUMANP61073IPR000174IL8_rcptInterleukin-8 receptor
7852CXCR4_HUMANP61073IPR005393Lymphotact_rcptLymphotactin receptor

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