Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:796
Official Symbol:CALCA
Other Aliases:CALC1|CGRP|CGRP-I|CGRP1|CT|KC|MGC126648
See related:HGNC:1437|MIM:114130|HPRD:00238
Chromosome:11
Location:11p15.2-p15.1
Gene Description:calcitonin/calcitonin-related polypeptide, alpha
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0402
ORGANISM:human
Entrez Gene ID:796
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12065639
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Downregulated
Fold Change:-1.6 :: -1.7 :: -1.9 :: -1.9 :: -2.1 :: -2.3
KARG Evidence 2
KARG ID:EVIM0470
ORGANISM:human
Entrez Gene ID:796
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12065639
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Motor Cortex
Drug Effects:Downregulated
Fold Change:-1.1 :: -1.1 :: -2.1 :: -6.4 :: -1.9
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
12310CBCerebellum24.524395465850835.8978805541992
12310CTXCerebral cortex20.170696020126314.2765286564827
12310HIPHippocampal region15.056499481201216.0733525753021
12310HPFHippocampal formation16.033467650413514.8470615148544
12310HYHypothalamus21.749299764633216.9352542161942
12310LSXLateral septal complex19.213114738464414.6511626839638
12310MBMidbrain17.637352108955415.5841765403748
12310MYMedulla23.227257251739530.1150226593018
12310OLFOlfactory bulb32.75214004516628.0921702384949
12310PPons22.340267181396529.3621487617493
12310PALPallidum19.197995543479915.9759848117828
12310RHPRetrohippocampal region18.936064839363114.0825632810593
12310sAMYStriatum-like amygdalar nuclei8.575729489326486.48086827993393
12310STRStriatum11.26839232444768.06192442774773
12310STRdStriatum dorsal region8.144639432430275.76684617996216
12310STRvStriatum ventral region19.837838292121913.1691060066223
12310THThalamus20.155804395675716.243720293045
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
796GO:0001501TASProcessskeletal development
796GO:0005179IEAFunctionhormone activity
796GO:0005615TASComponentextracellular space
796GO:0005625TASComponentsoluble fraction
796GO:0005783TASComponentendoplasmic reticulum
796GO:0007188TASProcessG-protein signaling, coupled to cAMP nucleotide second messenger
796GO:0007190TASProcessadenylate cyclase activation
796GO:0007202TASProcessphospholipase C activation
796GO:0007204TASProcesselevation of cytosolic calcium ion concentration
796GO:0007267TASProcesscell-cell signaling
796GO:0008217NASProcessblood pressure regulation
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
NP_001732.1--CALCRLHPRD00238
NP_001732.1799NP_001733.1calcitonin receptorBIND151030
NP_001732.110203NP_005786.1calcitonin receptor-likeHPRD11809
NP_001732.110203NP_005786.1calcitonin receptor-likeHPRD11809
NP_001732.110267NP_005846.1receptor activity-modifying protein 1 precursorHPRD00238
NP_001732.110267NP_005846.1receptor activity-modifying protein 1 precursorHPRD05515
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
796CALCA_HUMANP06881IPR000443AmylinIslet amyloid protein
796CALCA_HUMANP06881IPR001693Calcitonin-likeCalcitonin-like
796CALCA_HUMANP06881IPR002163Calcitonin_BCalcitonin, beta type
796CALC_HUMANP01258IPR001693Calcitonin-likeCalcitonin-like
796CALC_HUMANP01258IPR001935Calcitonin_ACalcitonin, alpha type

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