Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:80198
Official Symbol:MUS81
Other Aliases:FLJ21012|FLJ44872
See related:HGNC:29814|MIM:606591|HPRD:09419
Chromosome:11
Location:11q13
Gene Description:MUS81 endonuclease homolog (S. cerevisiae)
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0242
ORGANISM:human
Entrez Gene ID:80198
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:15816859
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Prefrontal Cortex
Drug Effects:Upregulated
Fold Change:0.76
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
71711CBCerebellum100.0100.0
71711CTXCerebral cortex100.0100.0
71711HIPHippocampal region100.0100.0
71711HPFHippocampal formation100.0100.0
71711HYHypothalamus100.0100.0
71711LSXLateral septal complex100.0100.0
71711MBMidbrain100.0100.0
71711MYMedulla100.0100.0
71711OLFOlfactory bulb100.0100.0
71711PPons100.0100.0
71711PALPallidum100.0100.0
71711RHPRetrohippocampal region100.0100.0
71711sAMYStriatum-like amygdalar nuclei100.0100.0
71711STRStriatum100.0100.0
71711STRdStriatum dorsal region100.0100.0
71711STRvStriatum ventral region100.0100.0
71711THThalamus100.0100.0
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
80198GO:0000287IEAFunctionmagnesium ion binding
80198GO:0003676IEAFunctionnucleic acid binding
80198GO:0004518IEAFunctionnuclease activity
80198GO:0004519IEAFunctionendonuclease activity
80198GO:0005634IEAComponentnucleus
80198GO:0006259IEAProcessDNA metabolism
80198GO:0006281IEAProcessDNA repair
80198GO:0006310IEAProcessDNA recombination
80198GO:0016787IEAFunctionhydrolase activity
80198GO:0043565IEAFunctionsequence-specific DNA binding
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
NP_079404.2146956AAH16470.1EME1 proteinHPRD10937
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
80198MUS81_HUMANQ96NY9IPR006166ERCC4ERCC4

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